Dynamics are inherent characteristics of batch processes, and they may exist not only within a particular batch, but also from batch to batch. To model and monitor such two-dimensional (2D) batch dynamics, two-dimensional dynamic principal component analysis (2D-DPCA) has been developed. However, the original 2D-DPCA calculates the monitoring control limits based on the multivariate Gaussian di...

The influence of initial pH on growth and nutrient (total sugars, nitrogen, and phosphorous) consumption by Enterococcus faecium CECT 410 was studied during batch cultures in whey. With these data, two realkalized fed-batch fermentations were developed using different feeding substrates. The shift from homolactic to mixed acid fermentation, the biphasic kinetics observed for cell growth and nit...

We developed a dynamic flux balance model for fed-batch Saccharomyces cerevisiae fermentation that couples a detailed steady-state description of primary carbon metabolism with dynamic mass balances on key extracellular species. Model-based dynamic optimization is performed to determine fed-batch operating policies that maximize ethanol productivity and/or ethanol yield on glucose. The initial ...

The cost of fermentable sugars added as a substrate is one major problem for economic lactic acid (LA) production. Old oil palm trunks (OPT) squeezed sap, the agricultural wastes on replanting and pruning (Elaeis guineensis), contained mainly glucose fructose potential feedstock to use vast carbon source LA To improve yield productivity, various fermentation modes were performed by Lactobacillu...

BACKGROUND The bacteria Escherichia coli K4 produces a capsular polysaccharide (K4 CPS) whose backbone is similar to the non sulphated chondroitin chain. The chondroitin sulphate is one of the major components of the extra-cellular matrix of the vertebrate connective tissues and a high value molecule, widely employed as active principle in the treatment of osteoarthritis. It is usually obtained...

background and objectives : streptokinase is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction and is commonly prepared from cultures of streptococcus equisimilis strain h46a. the objective of the present study was the production of streptokinase from strain h46a and purification by chemical reduction method. materials and methods: the rate of...

An optimized feeding strategy for the fed-batch fermentation of 2-keto-L-gulonic acid (2-KGA) is proposed to enhance total profit a workshop. Instead assigning same quantity substrate each batch in empirical scheduling, online offers practical approach that allows precise management maximize economic performance. The forecasting function has been achieved through similarity measurement and mult...