Pavlovian fear conditioning is not a unitary process. At the neurobiological level multiple brain regions and neurotransmitters contribute to fear learning. At the behavioral level many variables contribute to fear learning including the physical salience of the events being learned about, the direction and magnitude of predictive error, and the rate at which these are learned about. These expe...

The amygdala, dorsal periaqueductal gray (dPAG), and medial hypothalamus have long been recognized to comprise a neural system responsible for the generation and elaboration of unconditioned fear in the brain. This neural substrate is well known to be under tonic inhibitory control exerted by γ-aminobutyric acid (GABA) mechanisms. Some evidence also suggests that these structures integrate cond...

This study explored the time course of conditioned fear response expression. Two neutral male facial expressions served as conditioned stimuli (CS) in a differential trace conditioning that involved either an aversive (n=14) or a nonaversive (n=12) unconditioned stimulus (UCS) in a between-subjects design. Skin conductance response (SCR) to the CSs and startle response magnitudes to acoustic pr...

Learning to initiate defenses in response to specific signals of danger is adaptive. Some chronic pain conditions, however, are characterized by widespread anxiety, avoidance, and pain consistent with a loss of defensive response specificity. Response specificity depends on ability to discriminate between safe and threatening stimuli; therefore, specificity might depend on sensory precision. Th...

UNLABELLED The present study examined whether pain catastrophizing and pain-related fear predict the experience of pain in body regions that are not targeted by an experimental muscle injury protocol. A delayed-onset muscle soreness (DOMS) protocol was used to induce pain unilaterally in the pectoralis, serratus, trapezius, latissimus dorsi, and deltoid muscles. The day after the DOMS protocol,...

Fear conditioning is an important test in behavioral neuroscience to investigate the neural systems and molecular basis of various aspects of emotional learning across a wide range of species [1]. Dysfunction of the fear circuits is assumed to underlie mechanisms of affective disorders and is frequently investigated in rodent models. Traditional fear conditioning methods require frequent handli...

To test predictions derived from the emotional processing theory of fear reduction, claustrophobics …N ˆ 58† were randomized to one of four exposure conditions: (a) exposure with guided threat reappraisal, (b) exposure with a cognitive load distracter task, (c) exposure with both guided threat reappraisal and cognitive load distracter task and (d) exposure without guided threat reappraisal or c...

The amygdala has been the focus of investigations of aversive learning, particularly Pavlovian fear conditioning paradigms in which fear is expressed passively, such as through autonomic responses (for review see Phelps and LeDoux, 2005). In contrast, the human striatum has been highlighted in investigations of reward-related processing, such as instrumental paradigms, that involve decision-mak...

There has been a renewed interest in the neural basis of fear conditioning to context. These current approaches are accompanied by some limitations including the use of short testing windows, non-discriminative paradigms, and unitary fear response assessment. In an attempt to circumvent these limitations, a discriminative context procedure assessing multiple response measures of fear was used i...