Exercise-induced muscle fatigue has been shown to be the consequence of peripheral factors that impair muscle fiber contractile mechanisms. Central factors arising within the central nervous system have also been hypothesized to induce muscle fatigue, but no direct empirical evidence that is causally associated to reduction of muscle force-generating capability has yet been reported. We develop...

BACKGROUND Prognostic models including age, self-rated health and prior sickness absence (SA) have been found to predict high (≥ 30) SA days and high (≥ 3) SA episodes during 1-year follow-up. More predictors of high SA are needed to improve these SA prognostic models. The purpose of this study was to investigate fatigue as new predictor in SA prognostic models by using risk reclassification me...

In order to successfully implement reliable Flip Chip packaging technology, it is desirable to ensure solder fatigue as the limiting mechanical failure mechanism. Doing so enables the packaging engineer to design to specific reliability standards, as solder fatigue is a known and predictable failure mechanism. Indeed, other Flip Chip failure modes such as silicon fracture and underfill delamina...

OBJECTIVES To determine the mediating effects of depression on health-related quality of life and fatigue in individuals with multiple sclerosis (MS). DESIGN A cross-sectional study. SETTING Tertiary urban hospital. PARTICIPANTS One hundred and eight patients (54% women) with MS participated in this study. OUTCOME MEASURES Demographic and clinical data (weight, height, medication and ne...

Service conditions of turbine blades involve fatigue, creep, and environmental corrosion. Themanner in which these mechanisms interact to initiate cracks is complex. These physicalmechanisms have been observed through observation and measurement of damage in adirectionally-solidified (DS) GTD-111 Ni-base superalloy. Experiments include high temperaturelow cycle fatigue with and ...

The objective of the current study was twofold: (a) to determine whether subgroups of breast cancer patients could be identified on the basis of their distinct trajectory or pattern of fatigue following treatment for early stage cancer using growth mixture modeling and (b) to examine whether the subgroups could be distinguished on the basis of a cognitive-behavioral model. Growth mixture modeli...

Tendinopathies are commonly attributable to accumulation of sub-rupture fatigue damage from repetitive use. Data is limited to late stage disease from patients undergoing surgery, motivating development of animal models, such as ones utilizing treadmill running or repetitive reaching, to investigate the progression of tendinopathies. We developed an in vivo model using the rat patellar tendon t...

driver fatigue may impose the risk of crashes and is a leading cause of death in transportation industry. this study aimed to detect driver cognitive fatigue based on changes in eeg frequency bands in non-professional drivers during a simulated driving task. in a descriptive-analytical study, 12 healthy male car drivers took part in a two hour driving session on a simulated monotonous road, whi...

OBJECTIVE The effects of fatigue on multiple-task performance were explored through computational cognitive modeling. BACKGROUND Fatigue typically has a negative impact on human performance. Biomathematical models exist that characterize the dynamics of human alertness, but the link between alertness and in situ performance on specific tasks is tenuous. Cognitive architectures offer a princip...