نتایج جستجو برای: fasudil
تعداد نتایج: 521 فیلتر نتایج به سال:
Rho-Associated kinases ROCK1 and ROCK2 have been extensively investigated in the pathogenesis of cardiovascular disease. However, their roles are not fully understood carcinogenesis. In this study, we whether or is required for survival growth hepatocellular carcinoma (HCC) cells underlying mechanism. ROCKs expression was determined human HCC tissue cell lines using qRT-PCR, western blotting, i...
INTRODUCTION Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt-planar cell polarity (Wnt-PCP) pathway to drive ...
AIMS Although stimulation with sphingosylphosphorylcholine (SPC) or sphingosine-1-phosphate (S1P) generally leads to similar vascular responses, the contractile patterns and their underlying signalling mechanisms are often distinct. We investigated the different reliance upon Ca2+-dependent and Ca2+-sensitizing mechanisms of constriction in response to SPC or S1P in coronary arteries. METHODS...
BACKGROUND AND PURPOSE Endothelium-derived nitric oxide (NO) plays a pivotal role in vascular protection. The Rho kinase (ROCK) inhibitor, hydroxyfasudil, prevents the downregulation of endothelial NO synthase (eNOS) under hypoxic conditions. However, it is unknown whether inhibition of ROCK can attenuate ischemia-induced endothelial dysfunction and tissue damage in vivo. METHODS Human vascul...
1 Galie N, Hoeper MM, Humbert M, et al. Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J 2009; 34: 1219–1263. 2 Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rhokinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522: 177–185. 3 Etienne-Manneville S, Hall A. Rho GTPases in cell biology. Nature 2002; 420: 629–635....
Abstract Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation increased cerebral blood flow (CBF) during neurovascular coupling via activation endothelial nitric oxide synthase (eNOS). Decreased vascular reactivity is suggested contribute i...
Ozawa Y, Kobori H. Crucial role of Rho-nuclear factorB axis in angiotensin II-induced renal injury. Am J Physiol Renal Physiol 293: F100–F109, 2007. First published April 4, 2007; doi:10.1152/ajprenal.00520.2006.—This study was performed to determine the effectiveness of the Rho kinase inhibitor and NFB inhibitor in renal injury of ANG II-infused hypertensive rats. Male Sprague-Dawley rats, mai...
BACKGROUND AND PURPOSE Cerebral cavernous malformations (CCMs) are characterized by grossly dilated capillaries, associated with vascular leak and hemorrhage, and occur in sporadic or inherited (autosomal-dominant) forms with mutations in 1 of 3 gene loci (CCM 1, 2 or 3). We previously reported that the CCM1 protein (KRIT1) localizes to endothelial cell-cell junctions and loss of KRIT1 leads to...
P ulmonary hypertension (PH) is characterised by progressive elevation of pulmonary artery pressure and pulmonary vascular resistance. Pathohistological findings have demonstrated that PH is associated with abnormal vascular structures, including medial and/or intimal hypertrophy, concentric or eccentric intimal fibrosis, obstruction in the arterial lumen, and aneurysmal dilatation. Patients wi...
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