Fatty acids (FAs) are essential for cell survival, yet their overaccumulation causes lipotoxicity. To prevent lipotoxicity, cells store excess FAs as triglycerides (TGs). In cultured cells TG synthesis is activated by excess unsaturated but not saturated FAs. Here, we identify Ubxd8 as a sensor for unsaturated FAs and regulator of TG synthesis. In cultured cells depleted of FAs, Ubxd8 inhibits ...

Background: Soluble FasL (sFasL) generating from Membrane-bound (mFasL) cleaved by matrix metalloproteinases (MMPs). sFasL inhibits the apoptotic and inflammatory activity of mFasL because competes with binds to Fas. To evaluate serum soluble Fas ligand level in patients chronic myeloid leukemia.
 Materials Method: Serum levels were measured ELISA method after venous blood was collected 56...

Kobieta, spożywając alkohol w czasie ciąży, może przyczynić się do wystąpienia u swojego dziecka problemów natury fizycznej, psychicznej, poznawczej i społecznej. Najbardziej niebezpiecznym powikłaniem jest alkoholowy zespół płodowy (fetal alcohol syndrome, FAS). Ważnym wskaźnikiem poziomu funkcjonowania osób z FAS system składniowy, ponieważ budowa wypowiedzeń stanowi wykładnik umiejętności zd...

Fas-Fas ligand interactions play a central role in the regulation of the immune response. Fas ligand expression by tumors has been implicated in the abrogation of the host antitumor response by killing of Fas-positive effector lymphocytes. We have studied the presence and functional status of Fas and Fas ligand in Ewing's sarcoma. All Ewing's sarcoma cell lines tested expressed Fas on their sur...

To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in placenta. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts res...

Fas/Apo-1 is a member of the TNF receptor superfamily that signals apoptotic cell death in susceptible target cells. Fas or Fas ligand (FasL)-deficient mice are relatively resistant to the induction of experimental allergic encephalomyelitis, implying the involvement of Fas/FasL in this disease process. We have examined the regulation and function of Fas expression in glial cells (astrocytes an...

Based on direct quaternion method, this paper explores the finite-time adaptive synchronization (FAS) of fractional-order delayed quaternion-valued fuzzy neural networks (FODQVFNNs). Firstly, a useful fractional differential inequality is created, which offers an effective way to investigate FAS. Then two novel control strategies are designed. By means our newly proposed inequality, basic knowl...

Despite advancements in research made over the past decades, the prognosis of gliomas remains dismal. Fas/Fas ligand (Fas-L)-related immunotherapy may be regarded as a treatment of choice as it can induce the apoptosis of glioma cells, and has shown promising results in experimental studies. Over the years, brain glioma stem cells (BGSCs) have been accepted as the origin of gliomas and determin...