نتایج جستجو برای: farnesyl dipho
تعداد نتایج: 1579 فیلتر نتایج به سال:
background: the family rosaceae, include some large genus, eg the genus rose includes 200 species and 18000 cultivars. objective: aim of this study is to determine the chemical composition of the hydrodistilled oil of the leaves of sanguisorba minor scop, of iranian origin for the first time. methods: the essential oil obtained by hydrodistillation of sanguisorba minor was analyzed by gc and gc...
PURPOSE This phase I study was conducted to determine the toxicities, pharmacokinetics, and pharmacodynamics of BMS-214662, a farnesyl transferase inhibitor, in combination with paclitaxel and carboplatin, in patients with advanced solid tumors. EXPERIMENTAL DESIGN Patients with solid tumors received one of six escalating dose levels of BMS-214662 infused over 1 hour given following paclitaxe...
This study explores the role of mevalonate inhibitors in the activation of NF-k b and the induction of inducible nitric oxide synthase (iNOS) and cytokines (TNFa , IL-1 b , and IL-6) in rat primary astrocytes, microglia, and macrophages. Lovastatin and sodium phenylacetate (NaPA) were found to inhibit LPSand cytokine-mediated production of NO and expression of iNOS in rat primary astrocytes; th...
BACKGROUND (-)-α-Bisabolol, also known as levomenol, is an unsaturated sesquiterpene alcohol that has mainly been used in pharmaceutical and cosmetic products due to its anti-inflammatory and skin-soothing properties. (-)-α-Bisabolol is currently manufactured mainly by steam-distillation of the essential oils extracted from the Brazilian candeia tree that is under threat because its natural hab...
An analysis of the x-ray structure of homodimeric avian farnesyl diphosphate synthase (geranyltransferase, EC 2.5.1.10) coupled with information about conserved amino acids obtained from a sequence alignment of 35 isoprenyl diphosphate synthases that synthesize farnesyl (C15), geranylgeranyl (C20), and higher chain length isoprenoid diphosphates suggested that the side chains of residues corres...
The Philadelphia (Ph) chromosome is found in approximately 3% of pediatric patients with acute lymphoblastic leukemia (ALL) and the percentage markedly increases in adult patients. The prognosis for this class of patients is poor, and no standard chemotherapy combination so far has demonstrated long-term efficacy. The Ph-translocation joins the BCR and ABL genes and leads to expression of a chi...
Capilloquinol (1), possessing an unprecedented farnesyl quinoid skeleton, was isolated from the Dongsha Atoll soft coral Sinularia capillosa. The structure of capilloquinol was elucidated by extensive analysis of spectroscopic data. The cytotoxicity and antiviral activity against human cytomegalovirus of 1 was evaluated in vitro.
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