The aim of this study was to develop a new pain management method called facilitated tucking by parents (FTP) to alleviate procedural pain in preterm infants in the Neonatal Intensive Care Unit (NICU). In two randomized controlled crossover trials, the effectiveness of FTP was compared to a non-pharmacological evidence-based practice (oral glucose), a pharmacological method (intravenous oxycodo...

Large genomes pose a challenge to DNA repair pathways because rare sites of damage must be efficiently located from among a vast excess of undamaged sites. Human alkyladenine DNA glycosylase (AAG) employs nonspecific DNA binding interactions and facilitated diffusion to conduct a highly redundant search of adjacent sites. This ensures that every site is searched, but could be a detriment if the...