Bone scintigraphy with 99mTc diphosphonates may exhibit extraosseous lesions in addition to metastatic lesions. Multiple factors can affect extraosseous 99mTc methylene diphosphonate (MDP) uptake. Similar uptake pattern of 99mTc MDP and fluorine-18 fluorodeoxyglucose (18F FDG) in hepatic metastasis was not already notified. In our case, initial tumor necrosis and subsequent intracellular calcif...

several cases reported in the literature1,3,5--7 (in addition to our case) where 18FDG-PET (alone or combined with CT) was of value for the localization of occult ECS due to carcinoid tumor. Moreover, various studies have shown its value in detecting neuroendocrine tumors in general (secreting and non-secreting),8,9 mainly atypical ones (showing greater hypermetabolism).10 The development of ne...

AIM 3'-deoxy-3'-[¹⁸F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors. METHODS Xenografts in mice from 3 human cancer cell lines were used...

PURPOSE We aimed to evaluate the usefulness of dual tracer positron emission tomography-computed tomography (PET-CT) with flourine-18 fluorodeoxyglucose (18F-FDG) and gallium-68 [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide (68Ga-DOTANOC) in preoperative characterization of large indeterminate adrenal masses. MATERIALS AND METHODS Ten patients (four males, six f...

Indoleamine 2,3-dioxygenase (IDO1) plays a special role in the biology of various cancer types, because it breaks down the essential amino acid tryptophan for immune cell activation. Upregulation of IDO1 significantly correlates with the number of various T cell types in tumor tissues in melanoma and other cancers, suggesting that IDO expression is linked with effective and ineffective ('exhaus...

OBJECTIVE To determine the efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the detection of radiation-induced myocardial damage in beagles by comparing two pre-scan preparation protocols as well as to determine the correlation between abnormal myocardial FDG uptake and pathological findings. MATERIALS AND METHODS The anterior myocardium ...

Radiolabeled tracers targeting the prostate-specific membrane antigen (PSMA) have become important radiopharmaceuticals for the PET-imaging of prostate cancer. In this connection, we recently developed the fluorine-18-labelled PSMA-ligand [18F]PSMA-1007 as the next generation radiofluorinated Glu-ureido PSMA inhibitor after [18F]DCFPyL and [18F]DCFBC. Since radiosynthesis so far has been suffer...

Abstract Background and aim There are no reports of quantitative evaluation metabolic changes in the mammary gland after radiation therapy. The purpose this study was to investigate ipsilateral therapy evaluate late effects. Patients methods Metabolic contralateral glands were retrospectively evaluated by F-18 fluorodeoxyglucose (FDG) PET/CT whole breast irradiation following lumpectomy five ca...

background: fluoride-18 is the most widely used radioisotope for positron emission tomography (pet). [18f] 2-flouro- 2-deoxy d-glucose (fdg) has become a standard tool in the area of clinical research. the oxygen-18 enriched water is the most widely used target for the production of fluoride-18. the use of the nuclear reaction 18o (p,n)18f has been found as the most effective method for the pro...