the inherited polyposis syndromes and colorectal carcinoma. Four patients are reported, to illustrate the wide spectrum of colonic polyps which may occur in multiple form in adults. Included are unusual cases of metaplastic and-juvenile polyposis. The subject is reviewed, and the need for accurate histological diagnosis is stressed. The possibility that the difference between familial adenomato...

Attenuated familial polyposis (AFAP) is a subset of familial adenomatous polyposis (FAP) that has a relatively benign disease course. AFAP is characterized by no more than 100 colorectal polyps and has a tendency toward rectal sparing, a 20–25-year delay in the onset of adenomatosis and bowel symptoms, a 10–15-year delay in the development of colorectal cancer, and death caused by colorectal ca...

Aetiology Smoking – increased RR x7 Analgaesic abuse Phenacetin most commonly described – increased RR 3.6x. Also associated with codeine, paracetamol and salyicylates Associated papillary necrosis on imaging associated with risk increase x7, which is synergistic with phenacetin abuse (20x) Characteristic finding of thickened basement membrane on histology – should alert physician to need for c...

Primary intimal sarcomas are uncommon and highly lethal tumors arising in the mesenchymal tissue of great arteries [1-3]. In this setting, primary Pulmonary Artery Sarcomas (PAS) are often misdiagnosed with a poor prognosis due to their extreme aggressiveness [1-3]. Conversely, Lynch Syndrome is an inherited disorder with an increased risk of developing colorectal cancer, and a well defined spe...

Introduction Hepatoblastoma is a rare hepatic malignancy that is seen in Familial Adenomatous Polyposis (FAP). The occurrence is four hundred fold higher than the general population [1]. Hepatoblastoma is generally treatable with surgery; in addition it is highly responsive to chemotherapy. While the literature reports on this extracolonic manifestation of FAP, no screening recommendations exis...

primary immunodeficiency diseases (pids) are rare but include severe conditions found predominantly in children, most pids have cutaneous manifestations that may be important as early diagnostic features. the purpose of this study was to determine the frequency and nature of cutaneous alterations associated with pids. this article is a cross-sectional study at the department of allergy and clin...

INTRODUCTION Splenoma or splenic hamartoma is a rare primary splenic tumor most often discovered radiologically and incidentally. Splenic hamartomas have a strong association with solid and hematological malignancies and, in rare cases, with tuberous sclerosis, but to the best of our knowledge no reports of splenic hamartomas associated with familial adenomatous polyposis have been documented, ...

We would like to draw your attention to the following three methodological issues. The first issue is about the use of the word “prospective” by the authors in the title of the study. The title of an article provides a glimpse of not only the topic discussed but also about the methodology used to achieve the result. Accordingly, readers might either choose to stop by, or forego reading the arti...

background: musculoskeletal manifestations (msm) of inflammatory bowel diseases (ibds) are usually the most frequent extraintestinal manifestations. however, they are not paid enough attention during regular office visits. this cross-sectional study aimed to draw a clinical picture of msm and their relationships with other findings in patients with ibd. materials and methods: patients of our ib...

children with autism spectrum disorders (asds) have great problems in social interactions including face recognition. there are many studies reporting deficits in face memory in individuals with asds. on the other hand, some studies indicate that this kind of memory is intact in this group. in the present study, delayed face recognition has been investigated in children and adolescents with asd...