نتایج جستجو برای: extracellular matrix metalloproteinase inducer emmprincd147

تعداد نتایج: 470331  

Journal: :International journal of oncology 2012
Takashi Sato Mami Watanabe Kei Hashimoto Tomoko Ota Noriko Akimoto Keisuke Imada Motoyoshi Nomizu Akira Ito

EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cells. EMMPRIN has also been associated with the control of migration...

2016
Deepak K. Kaushik Heather Y. F. Yong Jennifer N. Hahn Claudia Silva Steven Casha R. John Hurlbert Francois H. Jacques Robert Lisak Omar Khan Carolina Ionete Catherine Larochelle Alex Prat Amit Bar-Or V. Wee Yong

Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is an inducer of matrix metalloproteinases and has roles in leukocyte activation and migration. We reported previously that in MS and its animal model, experimental autoimmune encephalomyelitis, cell surface-associated EMMPRIN was significantly elevated in leukocytes around inflammatory perivascular cuffs in the CNS. In this study ...

2016
Xiaofeng Li Xiaozhou Yu Dong Dai Xiuyu Song Wengui Xu

Extracellular matrix metalloproteinase inducer, also knowns as cluster of differentiation 147 (CD147) or basigin, is a widely distributed cell surface glycoprotein that is involved in numerous physiological and pathological functions, especially in tumor invasion and metastasis. Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate across...

Journal: :Reproduction & fertility 2022

Graphical abstract Abstract The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes myometrial contraction labour at term or preterm appears to share some common mechanisms with occurrence, growth, invasion and metastasis cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases pivotal complex tissue modulation includes degradation, exchan...

2012
XINJIE YANG PU ZHANG QIN MA LIANG KONG YUAN LI BAOLIN LIU DELIN LEI

Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that is involved in tumor invasion by stimulating matrix metalloproteinase (MMP) expression. Our previous immunohistochemical study found that the expression of EMMPRIN in salivary adenoid cystic carcinoma (SACC) was positively correlated with tumor perineural and perivascular invasion. The present study wa...

2017
Xing Liang Li-Xia Yang Ruiwei Guo Yankun Shi Xianhua Hou Zhihua Yang Xiaobin Zhou Hong Liu

Extracellular matrix metalloproteinase inducer (EMMPRIN) reportedly has a key regulatory role in matrix metalloproteinase (MMP) activities and the progression of atherosclerosis. Statins, which are anti-atherosclerotic pharmacological agents, are widely applied in clinical settings. The aim of the present study was to investigate the pharmaceutical effect of atorvastatin on EMMPRIN expression i...

2017
Jiatian Cao Bozhi Ye Lu Lin Lei Tian Hongbo Yang Changqian Wang Weijian Huang Zhouqing Huang

Rupture of vulnerable atherosclerotic plaques is the leading cause of acute myocardial infarction (AMI) and unstable angina pectoris (UA). However, it still lacks an effective therapy to stabilize the vulnerable atherosclerotic plaques. Numerous reports have shown that upregulation of MMP-9 (matrix metalloproteinase-9) and EMMPRIN (extracellular matrix metalloproteinase inducer) in macrophages ...

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