Objective: In addition to assessing the phenotypic development of biofilms and beta-lactamases, in current study, Pseudomonas aeruginosa isolates from intensive care units (ICU) patients with prevalent drug resistance are being evaluated. Methods: Standard CLSI recommended protocols were utilized detect beta-lactamases such as extended-spectrum β-lactamases (ESBL), metallo beta-lactamase (MBL),...

Antimicrobial drug resistance is a global challenge for the 21st century with the emergence of resistant bacterial strains worldwide. Transferable resistance to β-lactam antimicrobial drugs, mediated by production of extended-spectrum β-lactamases (ESBLs), is of particular concern. In 2004, an ESBL-carrying IncK plasmid (pCT) was isolated from cattle in the United Kingdom. The sequence was a 93...

background and objectives: the pathogenic strains of escherichia coli cause severe septicemia, urinary tract infection and wound sepsis. resistance of this organism to the expanded-spectrum cephalosporins occurs via the production of extended-spectrum β-lactamases (esbls) such as tem and shv. these enzymes hydrolyze oxyimino cephalosporins (cefotaxime, ceftazidime) and monobactams (aztreonam). ...

conclusions according to our results, blatem-116 was the most frequent isolated esbl gene among the p. aeruginosa strains isolated from patients. results ciprofloxacin and piperacillin were the most efficient antipseudomonal agents. the results disclosed that 19 (16.37%) of the isolates were multidrug resistant and 8 (6.89%) were esbl-positive. of the 116 isolates, 30 (25.86%) were resistant to...

Multidrug resistance is quite common among non-fermenting Gram-negative rods, in particular among clinically relevant species including Pseudomonas aeruginosa and Acinetobacter baumannii. These bacterial species, which are mainly nosocomial pathogens, possess a diversity of resistance mechanisms that may lead to multidrug or even pandrug resistance. Extended-spectrum β-lactamases (ESBLs) confer...