Export and the readiness to export constitute the first step of international marketing, which are affected by both internal and external factors of firms. One of the most important internal  factors is the presence of skilled personnel. The purpose of this study was to define the relationship between staff qualification and encouragment with the readiness level of Iranian pharmacuetical firms ...

Different RNA species are rigorously discriminated and exported by distinct export factors, but this discrimination mechanism remains largely unknown. We previously showed, by RNA microinjection experiments, that intronless mRNAs are discriminated from U snRNAs based on their difference in RNA length. However, it was unclear how they are discriminated in the natural situation in which their nas...

The yeast Sac3:Cdc31:Sus1:Thp1 (TREX-2) complex facilitates the repositioning and association of actively transcribing genes with nuclear pores (NPCs)-"gene gating"-that is central to integrating transcription, processing, and mRNA nuclear export. We present here the crystal structure of Sus1 and Cdc31 bound to a central region of Sac3 (the CID domain) that is crucial for its function. Sac3(CID...

The total number of patents produced by a country (or the number of patents produced per capita) is often used as an indicator for innovation. Here we present evidence that the distribution of patents amongst applicants within many countries is well-described by power laws with exponents that vary between 1.66 (Japan) and 2.37 (Poland). We suggest that this exponent is a useful new metric for s...

Indiana exports reached $3.98 billion in the third quarter of 2000. That represents a 14.8% increase when compared to the third quarter of 1999. Over the first three quarters of 2000 Indiana exports totaled $12.3 billion, about $2 billion more than sales during the same period in 1999. If this pace continues in the final quarter, Indiana exports would exceed $16 billion for the year — the highe...

Purpose – The purpose of this paper is to seek to show how the implementation of different quality assurance programs (QAPs) affects international market access for horticultural processing firms in developing countries. Design/methodology/approach – A representative survey of 50 registered firms processing horticultural produce in Vietnam was conducted. Logistic regression models are used to a...

Institutions have been shown to be important for trade and growth. In particular, weak institutions may reduce the returns to product quality, harming domestic welfare and making it attractive to export to countries with strong institutions where quality is better rewarded. We model this alternative story as to why the “good apples are shipped out” and explore whether exporting ameliorates the ...

Within the framework of an n-commodity, n-factor, K-country loglinear model with identical Cobb–Douglas production coefficients and identical consumer-expenditure shares across countries, balanced trade, and a pattern of world endowments permitting positive outputs of all commodities in each country, it is shown that, given any mode of aggregating the n commodities into at most n − 1 industrial...

The Hdm2 oncoprotein inhibits p53 functions by two means: (i) it blocks p53's transactivation activity and (ii) it targets p53 for degradation in a proteasome-dependent manner. Recent data indicate that Hdm2 shuttles between the nucleus and the cytoplasm and that the regulation of p53 levels by Hdm2 requires its nuclear export activity. Two different models are consistent with these observation...

Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicat...