Insulin dependent diabetes mellitus (IDDM) results from irreversible loss of beta cells (beta-cells) of the pancreas. A Streptozotocin (STZ)-induced diabetes in animal model mimics, in some aspects, recent onset IDDM. This study was conducted to investigate the effect of nicotinamide on experimentally-induced IDDM. Thirty Spraque Dawley rats were divided into 3 groups; a control group, a diabet...

Background: For decades, it was suspected that diabetes contributed to poorer oral health and the increased frequency of periodontitis. More recently it was found that periodontitis could adversely affect glycemic control in diabetics. The aim of this study was to compare periodontal parameters with the metabolic sugar levels of diabetic and non-diabetic individuals. Materials and Methods: I...

the present study aimed to investigate the effectiveness of group cognitive behavioral therapy in reducing anxiety and depression and glycemic control in children with type i diabetes. the study was quasi- experimental with a pre-test, post-test design with control group. for this purpose, 30 children with diabetes were selected from imam reza hospital in mashhad. the children were randomly ass...

It is well known that adrenal corticosteroids have many biological effects on the carbohydrate metabolism. However, the mechanism of corticosteroids on carbohydrate metabolism has not been completely clarified and remains to be studied. In the present investigation, it was intended to study the effects of dietary carbohydrates on the experimental steroid diabetes induced by Ingles method in whi...

The diabetes causes alterations in various organ systems, including the male accessory sex glands. The prostate is very important in the reproductive process and it is a frequent target of malignant changes. The aim of this work was to demonstrate the histochemical and ultrastructural alterations in the prostate of diabetic animals. Two groups of animals were utilized: control and non-obese dia...

Type 1 diabetes (T1D) is one of the most common chronic disorders of childhood and adolescence and its incidence is rising worldwide, with an annual increase over the last years of about 3–4% [1]. Based on recent estimates, between 2005 and 2010, there will be a 70% increase in the prevalence of T1D, with a doubling of new cases in children younger than 5 years [1]. These data are worrisome giv...

Present world scenario globally, upto 2010, around 285 million people suffering from Type 2 diabetes making up about 90% of the cases. According to statistics, by 2030, this number is estimated to almost double. Diabetes mellitus occurs throughout the world, but is more common (especially Type 2) in the more developed countries. The greatest increase in prevalence is, however, expected to occur...

Type 1 diabetes should be perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing cells in the pancreatic islets in genetically susceptible individuals. The past 12 months have provided new insights both into the pathogenesis and treatment of this disease. Further evidence has been provided that insulin may be the c...