Background: Exosomes are a small subset of extracellular vesicles with size about 50 nm – 200 nm, which found in many body fluids. The exosome is rich various proteins and cargo that carries out the process transporting between cells context cell communication. This becomes potential new therapeutic modality triggering modulation activity target so ACSs-Exosome to modulate skin flap transplanta...

Exosomes secreted by normal and cancer cells carry and deliver a variety of molecules. To date, mechanisms referring to tumor exosome trafficking, including release and cell-cell transmission, have not been described. To gain insight into this, exosomes purified from metastatic melanoma cell medium were labeled with a lipid fluorescent probe, R18, and analyzed by spectrofluorometry and confocal...

Bladder cancer (Bca) is one of the most common tumors in urinary system. Cystoscopy biopsy a gold standard for diagnosis Bca clinic. However, cystoscopy invasive, costly and invasive process causing pain patients. Because cells are closely contact with urine, exosomes can pass through base membrane transport microRNA (miRNAs) to so detection exosome-derived miRNAs urine expected be new non-inva...

Defects of RNA metabolism have been increasingly identified in various forms of inherited neurological diseases. Recently, abnormal RNA degradation due to mutations in human exosome subunit genes has been shown to cause complex childhood onset neurological presentations including spinal muscular atrophy, pontocerebellar hypoplasia and myelination deficiencies. This paper summarizes our current ...

We propose that retroviruses exploit a cell-encoded pathway of intercellular vesicle traffic, exosome exchange, for both the biogenesis of retroviral particles and a low-efficiency but mechanistically important mode of infection. This Trojan exosome hypothesis reconciles current paradigms of retrovirus-directed transmission with the unique lipid composition of retroviral particles, the host cel...

Exosomes are membrane vesicles released by reticulocytes during their maturation into erythrocytes. They have a clearing function because of their enrichment with some proteins known to decrease or disappear from the cell surface during maturation, eg, acetylcholinesterase (AChE) and transferrin receptor (TfR), respectively. To better understand the molecular events leading to protein sorting i...

The eukaryotic circadian oscillators consist of autoregulatory negative feedback loops. However, little is known about the role of posttranscriptional regulation of RNA in circadian oscillators. In the Neurospora circadian negative feedback loop, FRQ and FRH form the FFC complex that represses frq transcription. Here, we show that FFC also binds frq RNA and interacts with the exosome to regulat...

The yeast nucleolar protein Nop8p has previously been shown to interact with Nip7p and to be required for 60S ribosomal subunit formation. Although depletion of Nop8p in yeast cells leads to premature degradation of rRNAs, the biochemical mechanism responsible for this phenotype is still not known. In this work, we show that the Nop8p amino-terminal region mediates interaction with the 5.8S rRN...

almost all rNa molecules are pro­ cessed by rNases to form mature rNas. in addition, many rNas are degraded, either because they are no longer needed or because they are aberrant. all of these functions—rNa processing, normal rNa degradation and rNa quality con­ trol—are carried out by the eukaryotic rNa exosome complex. in this issue of EMBO reports, the Lorentzen group provide struc­ tural in...

IMPORTANCE Overdiagnosis and overtreatment of indolent prostate cancer (PCA) is a serious health issue in most developed countries. There is an unmet clinical need for noninvasive, easy to administer, diagnostic assays to help assess whether a prostate biopsy is warranted. OBJECTIVE To determine the performance of a novel urine exosome gene expression assay (the ExoDx Prostate IntelliScore ur...