LEVEL: ADVANCED I n the first half of this two-part article (1), we introduced the physical principle behind infrared (IR) absorptions and experimental setups used for investigating protein samples. This second part concludes by focusing on the use of IR spectroscopic data in formulation stability studies and for characterizing protein secondary structures and related changes (e.g., resulting f...

Indian Journal of Pharmaceutical Sciences 542 July August 2008 occlusive, protective skin barrier and actively replenishes moisture for better skin protection thereby leaving the skin silky, smooth and hydrated. The repairing and protecting properties open up possibilities to formulate caring products for sensitive skin. Improving the product features and medicinal functionality further validat...

Methods of rapidly and accurately assessing the chemical stability of pharmaceutical dosage forms are reviewed with respect to the major degradation mechanisms generally observed in pharmaceutical development. Methods are discussed, with the appropriate caveats, for accelerated aging of liquid and solid dosage forms, including small and large molecule active pharmaceutical ingredients. In parti...

In patients with a cow’s milk protein allergy, the presence of these allergens in medicines, even trace amounts, can trigger serious allergic reactions. The study milk-related excipient prevalence 165 antiasthmatic based on information included Summary Product Characteristics, revealed lactose more than one third medicines. Since may suffer cross-contamination protein, results are an alert to h...

till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

Till date, most of the drugs have been given in conventional immediate release dosage form. Nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. Hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Despite the numerous uses of chitin and chitosan as new functional materials of high potential in various fields, they are still behind several directly compressible excipients already dominating pharmaceutical applications. There are, however, new attempts to exploit chitin and chitosan in co-processing techniques that provide a product with potential to act as a direct compression (DC) excipi...