Red cell exchange transfusions remain an effective but possibly underutilized therapy in the acute and chronic treatment of sickle cell disease. In sickle cell disease, increased blood viscosity can cause complications when the hemoglobin exceeds 10 g/dL even if this is due to simple transfusion. Red cell exchange can provide needed oxygen carrying capacity while reducing the overall viscosity ...

a survey of tissue oxygenation differences in intensive care patients with blood transfusion     haghighimoghadamy [1] *, valizadeh ma [2] , feizi a [3]     received: 26 dec, 2011 accepted: 7 mar, 2012     abstract   background & aims : greater than 75% patient that hospitalized in intensive care units has anemia. blood transfusion in icu is not recently and about 40-70% patients in intensive c...

Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulatio...

In this randomized, controlled non-inferiority trial, filtered sunlight was compared with conventional phototherapy for the treatment of hyperbilirubinemia in term and latepreterm neonates. The primary end point was efficacy, which was defined as a rate of increase in total serum bilirubin of less than 0.2 mg/dL/h for infants up to 72 hours of age or a decrease in total serum bilirubin for infa...

INTRODUCTION The Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) carried out a survey on the current use of anti-D immunoprophylaxis (IP) in Italy, on its ways of use and on the impact that it has had on decreasing haemolytic disease of the newborn (HDN), due to maternal-foetal incompatibility for the D antigen. MATERIALS AND METHODS The survey was carried out using a qu...

Exchange blood transfusion in cases of erythroblastosis foetalis is now an accepted form of treatment but a somewhat tedious one, especially if it has to be carried out in the early hours of the morning. It was, therefore, decided to try and see whether the time could be cut down by using two syringes, whereby blood was withdrawn from the infant into one while the other was being charged with b...

In a previous paper (Calladine et al., 1965) it was shown that during exchange transfusion with citrated blood an acidosis often developed in babies transfused on the first day of life, but not in those transfused on the third day or later. The acidosis in the babies concerned was sometimes severe, and was occasionally associated with clinical symptoms. It was concluded that in performing excha...

The acid-citrate-dextrose (ACD) solution used to preserve blood consists in effect of 2 parts trisodium citrate to 1 part citric acid. It forms a buffer solution such that the pH of bank blood less than 5 days old is, in our experience, 6 6 ± 0 * 2. It can be predicted, therefore, that infusion of ACD blood must lead to an initial acidosis, and that this will in due course be replaced by a meta...

The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century. Using a Clark-type multi-wire oxygen surface electrode and the dorsal skin fold chamber model of the awake Syrian golden hamster, local tissue pO(2) was analyzed in the thin striated skin muscle before and after administration of an...

Very high bilirubin levels can have devastating neurodevelopmental effects on infants including hearing loss and cerebral palsy. A previous study in our institution determined the rate of, and factors associated with, bilirubin values above exchange transfusion level. Since this study the Bhutani nomogram was introduced to help identify infants at risk of severe hyperbilirubinaemia. In our stud...