Ewing sarcoma is a rare but aggressive diseasemost common in young adults. This cancer is driven by a unique chimeric fusion oncogene but targeted strategies have been elusive. Here we report the identification of the protein kinase PKC-ß (PRKCB) as a disease-specific druggable target for treatment of Ewing sarcoma. We found that transcriptional activation of PRKCBwas directly regulated by the ...

Submit Manuscript | http://medcraveonline.com Introduction Ewing sarcoma is a bone tumor that has a predilection for long bones in teenagers. It accounts to approximately 6–10 % of all primary bone tumors in children; however, it seldom occurs outside of the bone, and very rarely in the epidural space [1]. Ewing sarcoma is composed of uncharacterized mesenchymal cells. The most common sites are...

ewing sarcoma (es) of the mandible is a rare malignancy with poor prognosis which can be misdiagnosed as odontogenic inflammatory lesions or infections. we present a 7-year old male child which had been previously misdiagnosed and treated as an odontogenic abscess. this reported case describes the clinical, radiological and histopathological findings of oral es with difficulties in management. ...

MEDI-573 is a human antibody that neutralizes insulin-like growth factor (IGF) I and IGFII. IGFs are overexpressed in multiple types of cancer; their overexpression is a potential mechanism for resistance to IGFI receptor (IGFIR)-targeting therapy. Effects of IGF on cell proliferation, differentiation, and survival are mediated through its binding to and activation of IGFIR or insulin receptor ...

MEDI-573 is a human antibody that neutralizes insulin-like growth factor (IGF) I and IGFII. IGFs are overexpressed inmultiple types of cancer; their overexpression is a potential mechanism for resistance to IGFI receptor (IGFIR)-targeting therapy. Effects of IGF on cell proliferation, differentiation, and survival are mediated through its binding to and activation of IGFIR or insulin receptor A...

A case of Ewing sarcoma in a 16-year-old girl with 47 XXXc karyotype is reported.

Primary Ewing sarcoma of the kidney is a very rare neoplasm that generally occurs in young adults. We report a 69-year-old woman with a history of breast cancer who on a routine annual bone scan was found to have a suspicious area over the right kidney. Computed tomography revealed a 16 by 15-cm mass that was removed by a radical nephrectomy. Pathologic examination confirmed the diagnosis of ...