How do we scale information extraction to the massive size and unprecedented heterogeneity of the Web corpus? Beginning in 2003, our KnowItAll project has sought to extract high-quality knowledge from the Web. In 2007, we introduced the Open Information Extraction (Open IE) paradigm which eschews handlabeled training examples, and avoids domainspecific verbs and nouns, to develop unlexicalized,...

Unexpected adverse preclinical findings (APFs) are not infrequently encountered during drug development. Such APFs can be functional disturbances such as QT prolongation, morphological toxicity or carcinogenicity. The latter is of particular concern in conjunction with equivocal genotoxicity results. The toxicologic pathologist plays an important role in recognizing these effects, in helping to...

Cost-effectiveness analysis (CEA) offers decision makers a structured, rational approach with which to improve the return on resources expended. But decades after its widespread promotion to the medical community, policy makers in the United States remain reluctant to use the approach formally. Indeed, the resistance to economic evidence in the United States in an era of evidence-based medicine...

Modern clinical practice relies on evidence-based medicine (EBM) and evidence-based guidelines (EBGs). The critical evaluation of EBGs value is therefore an essential step to further improve clinical practice. In our opinion, correlating levels of evidence and grades of recommendation can be an easy tool to quickly display internal consistence of EBGs.

Open Information Extraction (IE) is the task of extracting assertions from massive corpora without requiring a pre-specified vocabulary. This paper shows that the output of state-ofthe-art Open IE systems is rife with uninformative and incoherent extractions. To overcome these problems, we introduce two simple syntactic and lexical constraints on binary relations expressed by verbs. We implemen...

This study was conducted under the Italian Ministerial Decree D.M. 173/2016 which regulates assessment of Sediment Class Quality in Italy using ecotoxicological bioassay and chemical analysis (Weight-Of-Evidence model). The aim this work to evaluate real classification obtained by theoretically equivalent responses nine different combinations batteries based on six species: Aliivibrio fischeri ...

A major challenge in the evidence-based design (EBD) practice model has been in determining the degree of credibility of specific (or a body of) evidence. This challenge has remained one of the key impediments to the broader adoption of EBD. Borrowing from evidence-based medicine and evidence-based practice literatures, this paper proposes a framework for evaluating evidence in EBD. Key to the ...

BACKGROUND Two of the key steps in evidence based medicine (EBM) are being able to construct a clinical question and effectively search the literature to source relevant information. No evidence currently exists that informs whether such skills should be taught to medical students during their pre-clinical years, or delivered to include both the pre-clinical and clinical years of study. This is...

The paper presents the results on development of an optical coating for a single-crystal ZnGeP2 substrate based selenide-oxide pair materials (ZnSe/Al2O3). obtained ensures operation OPO in mid-IR range up to 5 μm wavelengths. possibility ZnSe sputtering by IBS method is shown. has high laser-induced damage threshold (LIDT) value at 2097 µm wavelength: WoE=3.51 J/cm2 energy density and WoP= 101...