Most, if not all, ingested protein is degraded into amino acids, which are then absorbed. Absorption of amino acids has been studied in intact animals, everted gut sacs, and in other preparations of intestine. These studies have been reviewed recently (1, 2). Comparatively little is known, however, about amino acid absorption in the human. Kuroda and Gimbel (3) showed that when racemic amino ac...

Complexing a drug may alter the rate and extent of drug absorption. The complex formation is very well applied in the administration of poorly water-soluble drugs. The drugs selected for the study are cyclooxygenase-2 inhibitors, are potent anti-infl ammatory drugs with very low water solubility. The water solubility of these drugs was enhanced by complexing with β-cyclodextrin. In vitro absorp...

Rhizoma coptidis is a rhizome commonly used in traditional Chinese medicine. After oral administration of rhizoma coptidis extract, the plasma concentrations of its effective alkaloid constituents are so low that their systemic therapeutic actions cannot be explained. This study aimed to investigate the influence of lipopolysaccharide (LPS) on the pharmacokinetics of the rhizoma coptidis alkalo...

During the development of the embryo, a process of cephalocaudal and lateral folding takes place with the result that part of the endoderm-lined cavity of the secondary or definitive yolk sac is incorporated into the embryo to form the primitive gut. In the cephalic part of the embryo, the primitive gut forms a blind ending tube, the foregut, separated from the ectodermally lined stomatodaeum b...

OBJECTIVE An increased expression of RELM-beta (resistin-like molecule-beta), a gut-derived hormone, is observed in animal models of insulin resistance/obesity and intestinal inflammation. Intestinal sugar absorption is modulated by dietary environment and hormones/cytokines. The aim of this study was to investigate the effect of RELM-beta on intestinal glucose absorption. RESEARCH DESIGN AND...

In mammals, copper (Cu) absorption occurs mostly in the small intestine, and some of the Cu transporters involved in its uptake have been characterised. In fish, however, the regions of the gut involved in Cu absorption and the membrane transport mechanisms responsible for gastrointestinal Cu uptake are unknown. Everted gut sacs and isolated perfused intestine of Clarias gariepinus were used to...