In the present research work pulsatile drug delivery system of Metoprolol tartrate tablets were formulated and developed by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated table...

Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followe...

The purpose of this study was to assess the bioavailability of two oral preparations of difluoromethylornithine (DFMO). The current preparation of DFMO is a liquid with a concentration of 0.2 gram/ml that must be drawn up into a syringe and dispensed into a small medicine glass. This form of DFMO causes wastage of the medication. The liquid form also makes compliance and blinding difficult. Rec...

Doxazosin mesylate (DXM) sustained release pellets were prepared by an extrusion-spheronization and fluid-bed coating technique. The core pellets containing DXM were prepared by extrusion-spheronization technique, and coated by a fluid-bed coater to control the release of DXM. The factors affecting to properties of pellets, such as diluent content, type and coating level of coating agents and p...

importers of " Plasmoquine" into India, Burma and Ceylon, I would like, however, 011 behalf of the manufacturers, to make a short remark on the statement of the authors 011 p. 503. " The tablets made as they are at present are unsuitable for use in the damp tropical climate; no sooner is the stopper of the bottle opened than their sugar-coating melts and they run together into a sticky mass." T...

The aim of the study was to investigate the bioavailability of a generic product of 500 mg cefuroxime axetil film-coated tablets (test) as compared to that of a branded product (reference) at the same strength to determine bioequivalence and to apply for regulatory approval. The secondary objective of the study was to evaluate tolerability of both products. A double blinded, randomized, crossov...

Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media pH. Methods: Different formulations slow-release matrix tablets were polymers, namely, ethyl cellulose (Etc), hydroxyethyl (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using embedding technique. The characterized studies their prof...

The purpose of this research was to study the aqueous-based film coating of tablets utilizing a laboratoryscale side-vented perforated pan-coating apparatus. The process parameters of potential importance with respect to the final film quality were evaluated by using trial and error method. Tablets were evaluated for coating uniformity (mg), coating process efficiency (%), surface roughness, an...

The study is aimed to assess the compatibility of bilberry leaf powder extract (BLPE) with six excipients selected for sustained-release (SR) tablet formulation. BLPE was obtained addition L-arginine and Myo-inositol as carriers. Thermogravimetric (TG-DTG) analysis Fourier-transform infrared spectroscopy (FTIR), supported by Pearson correlation analysis, were applied detect possible interaction...

The influence of various polymers on the release rate of lithium carbonate from matrix-type tablets was investigated in an attempt to formulate a sustained release solid dosage form. For this purpose, tablets containing 450 mg of lithium carbonate along with various amounts of Carbopol 934P, 971P, 974P, Pemulen and Eudragit RLPO as retarding agents and inactive ingredients (e.g. PVP, Avicel or ...