Leishmania amastigotes parasitize almost exclusively the mononuclear phagocytes of mammals. The organisms survive and multiply within acidified vacuoles (parasitophorous vacuoles; p.v.) akin to phagolysosomes. Certain amino acid esters are known to accumulate in and disrupt lysosomes. We postulated that, since Leishmania possess lysosome-like organelles, they may be susceptible to the potential...

A new UV-spectrophotometric method for determining the concentration of benzyl fragments in heparin esters is proposed. The was validated linearity, accuracy, and precision terms repeatability intralaboratory reproducibility. intended to characterize esters, which are intermediates synthesis low-molecular-weight via hydrolytic depolymerization high-molecular-weight heparin.

Phthalic acid esters are presently being used in amounts and products that can easily, although inadvertently, contribute to environmental pollution. As plasticizers, phthalic acid esters are added to synthetic plastic resins to impart flexibility to the finished product, improve workability during fabrication, and extend or modify properties not present in the original resins (1). Plastic form...

Stearoyl-CoA desaturase (SCD) is a microsomal rate-limiting enzyme in the cellular synthesis of monounsaturated fatty acids (MUFA), mainly oleate (18:1) and palmitoleate (16:1), which are the major MUFA of membrane phospholipids, cholesterol esters and triglycerides. Three well-characterized isoforms of SCD, SCD1, SCD2 and SCD3, exist in mice. To investigate the physiologic functions of SCD1, w...

Reaction of the sulfuric acid ester of /V-hydroxy-4acetylaminobiphenyl and of the acetic acid esters of /V-hydroxy-4-acetylaminobiphenyl, /V-hydroxy-4-acetylaminostilbene, and /V-hydroxy-2-acetylaminophenanthrene with transforming DNA of Bacillus subtilis in vitro caused both inactivation of transforming activity and the induction of mutations. The parent amides, amines, /V-hydroxy amides, and ...

SUMMAR,Y Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d < 1.006 (VLDL), low-density lipoproteins of d 1.006-1.063 (LDL) and highdensity lipoproteins of d 1.063-1.21 (HDL). Transfer of glycerides from the VLDL to the LDL and HD...

The methyl esters of carboxylic acids are characteristic olfactory volatile compounds for the sweet aroma of snake fruit, (Salacca edulis, Reinw) cv. Pondoh. Although methanol was not detected as a volatile constituent, the crude enzymes showed activity to synthesize the methyl esters in the presence of acyl-CoA and methanol. Therefore, the biosynthetic origin of methanol was investigated, resu...

the seed of croton tiglium l. (sct) is a well known folk medicine. in china, it has used to treat gastrointestinal disorders, intestinal inflammation, rheumatism, and so on. previous studies established its purgative and inflammation properties. in addition, the effects of essential oil of sct on intestinal transit and gastrointestinal tract has been studied. in the present study, we evaluated ...

Esters of 2-iodoxybenzoic acid (IBX-esters) are potentially valuable oxidizing reagents belonging to a new class of pentavalent iodine compounds with a pseudo benziodoxole structure.

zn/acoh on silica gel converts a range of structurally different sulfoxides to their corresponding thioethers in excellent yields under microwave irradiation. it has been found that chemoselective deoxygenation of sufoxides can be achieved in the presence of other reducible functional groups such as acetals, acids, amides,   esters, ketones and nitriles.