BACKGROUND Nighttime reflux has been shown to be associated with esophageal mucosal injury, complications, and extra-esophageal manifestations. However, few studies have assessed the impact of gastroesophageal reflux on reported quality of sleep and quality of sleep on gastroesophageal reflux. AIMS The aims of this study were (1) to determine the correlation between the severity of gastroesop...

PURPOSE Studies of endoscopic application of radiofrequency energy to the lower esophageal sphincter for gastroesophageal reflux control have produced conflicting reports of its effectiveness. This study aimed to conduct a meta-analysis of randomized controlled trials and cohort studies to assess the impact of this treatment. METHODS Twenty studies were included. Outcomes analyzed included ga...

BACKGROUND Gastroesophageal reflux disease is a worldwide prevalent condition that exhibits a large variety of signs and symptoms of esophageal or extra-esophageal nature and can be related to the esophagic adenocarcinoma. In the last few years, greater importance has been given to the influence of physical exercises on it. Some recent investigations, though showing conflicting results, point t...

. Demonstrate an understanding of the natural history and manifestations of reflux disease . Evaluate the role of diagnostic testing such as endoscopy, esophageal manometry, ambulatory pH monitoring, and impedance-pH monitoring in the management of patients with gastroesophageal reflux disease . Evaluate the options for treatment of patients with complicated and uncomplicated reflux disease.

Salivary pH is associated with esophageal acid reflux and neutralization of esophageal acid. In this study, we assessed the association between nocturnal decline of salivary pH and airway hyperresponsiveness. Salivary pH was serially assessed in 9 patients with mild asthma (7 men and 2 women; mean age 33.3 years; mean %predicted FEV(1.0) 89.4%) and 10 healthy volunteers (6 men and 4 women; mean...

CONTEXT In infants, it is not always easy to distinguish between pathological and physiological gastroesophageal reflux based only on clinical criteria. In Brazil, studies about gastroesophageal reflux disease in infants are few and are even rare those that used prolonged esophageal pH monitoring for its evaluation. OBJECTIVE To describe the clinical features of gastroesophageal reflux diseas...

Combined multichannel intraesophageal impedance-pH (MII-pH) monitoring is currently the the gold standard method to diagnosis of gastroesophageal reflux disease (GERD). A standard MII-pH catheter has six pairs of impedance electrodes. Multiple impedance-measuring within the esophagus allows determination of direction of bolus movement within the esophagus. So that MII is used as a good esophage...

. Demonstrate an understanding of the natural history and manifestations of reflux disease . Evaluate the role of diagnostic testing such as endoscopy, esophageal manometry, ambulatory pH monitoring, and impedance-pH monitoring in the management of patients with gastroesophageal reflux disease . Evaluate the options for treatment of patients with complicated and uncomplicated reflux disease.

The opossum esophagus, like that of humans, contains a network of submucosal glands with the capacity to secrete bicarbonate ions into the esophageal lumen. To evaluate the role of these glands in protecting the epithelial surface from acid insult, we measured the lumen-to-surface pH gradient in opossum esophagus at different luminal pH and compared it to that of rabbit esophagus, an organ devo...

BACKGROUND Preoperative esophageal manometry and 24-hour pH monitoring commonly are used in preoperative evaluation of patients undergoing fundoplication. Here we review our experience with the selective preoperative workup of patients undergoing fundoplication to treat gastroesophageal reflux disease. STUDY DESIGN A series of 628 consecutive antireflux procedures was reviewed. History and ph...