Megaesophagus is defined as the abnormal enlargement or dilatation of the esophagus, characterized by a lack of normal contraction of the esophageal walls. This is called achalasia when associated with reduced or no relaxation of the lower esophageal sphincter (LES). To date, there are few naturally occurring models for this disease. A colony of transgenic (Pvrl3-Cre) rats presented with megaes...

Peroral endoscopic myotomy (POEM) is the application of esophageal myotomy to the concept of natural orifice transluminal surgery (NOTES) by utilizing a submucosal tunneling method. Since the first case of POEM was performed for treating achalasia in Japan in 2008, this procedure is being more widely used by many skillful endosopists all over the world. Currently, POEM is a spotlighted, emergin...

This paper presented a case of esophageal achalasia treated by peroral endoscopic myotomy with HybridKnife and discuss the feasibility and the possible advantages of using it.

Objective: Achalasia is a disease characterized by lower esophageal sphincter motility disorder. Whereas there no clear algorithm in treating achalasia children, Heller myotomy known to be as the most effective method. Gastroesophageal reflux after frequently reported complication. Therefore, fundoplication procedure should added simultaneously. Our study aimed present results of patients who u...

AIM To assess reference values in the literature for esophageal distensibility and cross-sectional area in healthy and diseased subjects measured by the functional lumen imaging probe (FLIP). METHODS Systematic search and review of articles in Medline and Embase pertaining to the use of FLIP in the esophagus was conducted in accordance with the PRISMA guidelines. Cross-sectional area and dist...

Achalasia cardia is a motility disorder, involving the distal esophagus, resulting in elevated lower esophageal sphincter pressure, increased intraesophageal pressure, incomplete relaxation of lower esophageal sphincter in response to deglutition and loss of esophageal peristalsis. It usually presents between third and fifth decades of life with the most common symptom of dysphagia. We present ...

BACKGROUND Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma was evaluated. METHODS This was a single-centre, retrospective study. Fifteen consecutive patients with esophageal achalasia who underwent POEM in our institution between August...

Achalasia is an uncommon primary motor disorder of the esophagus with an annual incidence of 0.8/100,000. Very few cases of coexistent Barrett’s esophagus (BE) and achalasia in patients without prior surgical myotomy or pneumatic dilation have been reported. We report the case of a 65-year-old female who was diagnosed with achalasia in June 2002. Endoscopy at that time revealed biopsy-confirmed...

OBJECTIVE To review the current management of achalasia, and the controversies regarding the different treatment options. METHODS A review of the literature was performed. The key words used were esophageal achalasia, Heller myotomy, endoscopic balloon dilatation, laparoscopic Heller myotomy, and fundoplication. RESULTS Patients who fail medical therapy (e.g. pharmacologic therapy, botulinu...

INTRODUCTION A paper presented a case of esophageal achalasia with both type 2 and type 3 achalasia found in the same patient. CASE OUTLINE High resolution impedance manometry of esophagus was performed. Liquid swallows induced panesophageal pressurization (achalasia type 2), whereas viscous swallows led to compartmentalized pressurization--distal two thirds of esophagus (achalasia type 3). N...