نتایج جستجو برای: escitalopram

تعداد نتایج: 1125  

Journal: :Maturitas 2012
Andrea Z LaCroix Ellen W Freeman Joseph Larson Janet S Carpenter Hadine Joffe Susan D Reed Katherine M Newton Rebecca A Seguin Barbara Sternfeld Lee Cohen Kristine E Ensrud

OBJECTIVE To evaluate the effects of escitalopram 10-20 mg/day on menopause-related quality of life and pain in healthy menopausal women with hot flashes. STUDY DESIGN A double-blind, placebo-controlled randomized trial of escitalopram 10-20mg/day vs. identical placebo was conducted among 205 women ages 40-62 years with an average of ≥4 daily hot flashes recruited at 4 clinical sites from Jul...

2011
Ulla Knorr Maj Vinberg Allan Hansen Marianne Klose Ulla Feldt-Rasmussen Linda Hilsted Jørgen Hasselstrøm Ulrik Gether Per Winkel Christian Gluud Jørn Wetterslev Lars Vedel Kessing

INTRODUCTION The mechanisms by which selective serotonin re-uptake inhibitors (SSRI) act in depressed patients remain unknown. The serotonergic neurotransmitter system and the hypothalamic-pituitary-adrenal (HPA) system may interact. The aim of the AGENDA trial was to investigate whether long-term intervention with SSRI versus placebo affects the cortisol response in the dexamethasone corticotr...

Journal: :International clinical psychopharmacology 2009
Siegfried Kasper Julia Sacher Nikolas Klein Nilufar Mossaheb Trawat Attarbaschi-Steiner Rupert Lanzenberger Christoph Spindelegger Susanne Asenbaum Alexander Holik Robert Dudczak

Escitalopram the S-enantiomer of the racemate citalopram, is clinically more effective than citalopram in the treatment of major depressive disorder. However, the precise mechanism by which escitalopram achieves superiority over citalopram is yet to be determined. It has been hypothesized that the therapeutically inactive R-enantiomer competes with the serotonin-enhancing S-enantiomer at a low-...

Journal: :Journal of analytical toxicology 2009
Björn Carlsson Anita Holmgren Johan Ahlner Finn Bengtsson

Citalopram is marketed as a racemate (50:50) mixture of the S(+)-enantiomer and R(-)-enantiomer and the active S(+)-enantiomer (escitalopram) that possess inhibitory effects. Citalopram was introduced in Sweden in 1992 and is the most frequently used antidepressant to date in Sweden. In 2002, escitalopram was introduced onto the Swedish market for treatment of depression and anxiety disorders. ...

Journal: :The international journal of neuropsychopharmacology 2008
Egemen Savaskan Sandra E Müller Andreas Böhringer André Schulz Hartmut Schächinger

Depression is a common disorder in the elderly handicapping patients with affective and cognitive symptoms. Because of their good tolerability relative to the older tricyclic compounds, selective serotonin reuptake inhibitors (SSRIs) are increasingly used for the treatment of depression in the elderly. Little is known about their effects on cognition in elderly patients. In the present 4-wk, si...

2014
Christoffer Rahm Benny Liberg Maria Kristoffersen-Wiberg Peter Aspelin Mussie Msghina

BACKGROUND AND OBJECTIVE Our aim was to study the regulatory role of serotonin [(5-hydroxytryptamine (5-HT)] on two key nodes in the cognitive control networks - the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC). We hypothesized that increasing the levels of 5-HT would preferentially modulate the activity in ACC during cognitive control during interference by ne...

Journal: :The journal of international advanced otology 2017
Olcay Kıroğlu Özgür Sürmelioğlu Mete Kıroğlu

OBJECTIVE To evaluate the effects of selective serotonin re-uptake inhibitors (SSRIs) on Meniere's disease (MD) on patients who have both MD and generalized anxiety disorder. MATERIALS AND METHODS All patients were evaluated with neurotologic examination, videonystagmography, audiological tests, and inner ear magnetic resonance imaging. Characteristic history and the evaluation of the patient...

Journal: :Fertility and sterility 2012
Janet S Carpenter Katherine A Guthrie Joseph C Larson Ellen W Freeman Hadine Joffe Susan D Reed Kristine E Ensrud Andrea Z LaCroix

OBJECTIVE To estimate the effect of escitalopram (10-20 mg/d) versus placebo for reducing hot flash interference in daily life and understand correlates and predictors of reductions in hot flash interference, a key measure of quality of life. DESIGN Multisite, randomized, double-blind, placebo-controlled clinical trial. SETTING MsFLASH clinical sites in Boston, Indianapolis, Oakland, and Ph...

2016
Satoshi Asakura Taiji Hayano Atsushi Hagino Tsukasa Koyama

PURPOSE To investigate the safety, tolerability, and effectiveness of escitalopram in patients with social anxiety disorder in Japan. METHODS A 52-week, open-label study was conducted in Japanese patients with social anxiety disorder with a total score ≥60 on the Liebowitz Social Anxiety Scale - Japanese Version (LSAS-J) and ≥4 on the Clinical Global Impression - Severity Scale. Escitalopram ...

Journal: :European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2010
Jiaojie Hui Zhijun Zhang Shanshan Liu Guangjun Xi Xiangrong Zhang GaoJun Teng Kevin C Chan Ed X Wu Binbin Nie Baoci Shan Lingjiang Li Gavin P Reynolds

Early life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague-Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180 min from po...

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