The aim of the present paper is to obtain a number of Kuhn-Tucker type sufficient optimality conditions for a feasible solution to be an efficient solution under the assumptions of the new notions of weak strictly pseudo quasi α-univex, strong pseudo quasi α-univex, and weak strictly pseudo α-univex vector valued functions. We also derive the duality theorems for Mond-Weir and general Mond-Wei...

Authors/writing members: Joost Daemen1, Maarten L. Simoons1, William Wijns2, Adrian Bagust3, Gert Bos4, James M. Bowen5, Eugene Braunwald6, Edoardo Camenzind7, Bernard Chevalier8, Carlo DiMario9, Jean Fajadet10, Anselm Gitt11, Giulio Guagliumi12, Hans L. Hillege13, Stefan James14, Peter Jüni15, Adnan Kastrati16, Sabine Kloth17, Steen D. Kristensen18, Mitchell Krucoff19, Victor Legrand20, Matthi...

Based on previous experience with parenteral prostanoids, we studied the effect of misoprostol treatment, an orally administered prostaglandin E1 analog, in patients with erythromelalgia. Treatment with placebo was followed by treatment with misoprostol (0.4-0.8 mg per d), both for 6 wk. The patients (n = 21) and a study nurse who administered the trial were blinded. The endpoints were change i...

Little is known about the contribution of C-afferent fibres to chronic painful conditions in humans. We sought to investigate the role of C-fibres in the pathophysiology of pain and hyperalgesia in erythromelalgia as a model disease for chronic pain. Erythromelalgia is a condition characterized by painful, red and hot extremities, and patients often report tenderness on walking. We made microne...

Serotonin has been shown to play a significant role in diseases related to vascular dysregulation like Raynaud’s phenomenon (Hollenberg, 1988), erythromelalgia (Rudikoff and Jaffe, 1997),migraine (Bonvento et al., 1991) and perimenopausal hot flushes (Berendsen, 2000). In recent years there have been several reports on the efficacy of the selective serotonin reuptake inhibitors (SSRIs) fluoxeti...

A 17-year-old white woman presented with a 2-year history of increasingly frequent episodes of erythromelalgia involving her hands, feet, and lower legs (Figure). She described the discomfort as “throbbing, burning, stinging.” Her symptoms occurred daily. The episodes involved her feet about 10 to 15 times during the day and involved her hands slightly less frequently. Whenever her feet got war...

A 17-year-old white woman presented with a 2-year history of increasingly frequent episodes of erythromelalgia involving her hands, feet, and lower legs. She described the discomfort as "throbbing, burning, stinging." Her symptoms occurred daily. The episodes involved her feet about 10 to 15 times during the day and involved her hands slightly less frequently. Whenever her feet got warm at nigh...

We report on aetiological factors, clinical findings and prognosis of 87 patients with erythromelalgia (EM). This is the largest material reported in the western literature. There is a 100% follow up of patients with observation period up to 11 years. There were 61 females and 26 males. About two-thirds of the patients were primary cases and around three-quarters had a chronic condition. The co...