PURPOSE Perillyl alcohol (POH) displays preventive and therapeutic activity against a wide variety of tumor models, and it has been suggested that this might be associated with the ability of POH to interfere with Ras prenylation. POH also selectively induces G(1) arrest and apoptosis in Bcr/Abl-transformed hematopoietic cells. Because signaling through Ras is necessary for Bcr/Abl transformati...

HS is a chronic inflammatory skin disorder and often associated with neoplastic growth of cSSC. Between 1%-3.2% patients develop cSCC, however, the molecular pathogenesis this disease remains undefined. Here, we demonstrate pathogenic role for 5’cap-binding protein complex eIF4F in lesion-associated This composed scaffold eIF4G, cap-binding eIF4E DEAD-box helicase eIF4A1. Employing confocal mic...

Abstract Aberrant Wnt signaling drives a number of cancers through regulation diverse downstream pathways. Wnt/?-catenin achieves this in part by increasing the expression proto-oncogenes such as MYC and cyclins. However, global assessment Wnt-regulated transcriptome vivo genetically distinct demonstrates that suppresses many genes it activates. In study, we examined set are upregulated upon in...

The G-protein-coupled receptor GPR84, activated by medium-chain fatty acids, primarily expressed in macrophages and microglia, is involved inflammatory responses retinal development mammals amphibians. However, our understanding of its structure, function, tissue expression, signaling pathways fish limited. In this study, we cloned characterized the coding sequence GPR84 (ciGPR84) grass carp. A...

We examined the effects of tick SGx and saliva on basal- and platelet-derived growth factor (PDGF)-stimulated cell migration and extracellular signal-regulated kinase (ERK) signaling in fibroblasts. Repair of injured monolayers was delayed by SGx pretreatment and was not associated with reductions in cell number. In migration assays, SGx suppressed both basal- and PDGF-stimulated fibroblast mov...

PURPOSE The constitutive activation of the Ras-MEK-ERK signaling pathway in oral cavity squamous cell carcinoma (OSCC) has been found to be tightly controlled at multiple levels under physiological conditions. RASA1 and SPRED1 are two important negative regulators of this pathway, but the exact regulating mechanism remains unclear. In this study, we aimed to explore the potential regulating mec...

The ocular lens is the only organ that does not develop spontaneous tumor. The molecular mechanism for this phenomenon remains unknown. Through examination of the signaling pathways mediating stress-induced apoptosis, here we presented evidence to show that different from most other tissues in which the extracellular signal-regulated kinases (ERKs) pathway is generally implicated in mediation o...

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Myeloid-derived suppressor cells (MDSCs) play an important role in tumor immune escape. Recent studies have shown that MDSCs contribute to progression under psychological stress, but the underlying mechanism of mobilization and recruitment remains largely unknown. In present study, a chronic restraint stress paradigm was applied H22 hepatocellular carcinoma (HCC) bearing mice mimic stress. We o...

Apoptosis, a major pathogenesis of cerebral ischemia, is closely associated with the dysregulation of MAPK/ERK signaling pathway. The transplantation of neural stem cells (NSCs), as a therapeutic target of cerebral ischemia, could repair missing cells and the activation of endogenous cells to provide "self-repair". However, the neuroprotective mechanism of the transplantation of NSCs against ce...