نتایج جستجو برای: erβ antagonist

تعداد نتایج: 59498  

2017
Takeshi Obata Mitsuhiro Nakamura Yasunari Mizumoto Takashi Iizuka Masanori Ono Jumpei Terakawa Takiko Daikoku Hiroshi Fujiwara

Although histological grade and muscular invasion are related to the malignant behaviors of endometrial endometrioid carcinoma, lymphatic and/or distant metastases are unexpectedly encountered, even in patients in the low-risk group. To re-evaluate additional reliable parameters to predict the risk of progression, we examined the immunohistochemical expression profiles of p53 and estrogen recep...

Journal: :Chemical research in toxicology 2011
Erin K Shanle Wei Xu

Many endocrine disrupting chemicals (EDCs) adversely impact estrogen signaling by interacting with two estrogen receptors (ERs): ERα and ERβ. Though the receptors have similar ligand binding and DNA binding domains, ERα and ERβ have some unique properties in terms of ligand selectivity and target gene regulation. EDCs that target ER signaling can modify genomic and nongenomic ER activity throug...

2015
Yan-Si Xiong Fang-Fang Liu Dan Liu He-Zhou Huang Na Wei Lu Tan Jian-Guo Chen Heng-Ye Man Cheng-Xin Gong Youming Lu Jian-Zhi Wang Ling-Qiang Zhu

The two estrogen receptors (ERs), ERα and ERβ, mediate the diverse biological functions of estradiol. Opposite effects of ERα and ERβ have been found in estrogen-induced cancer cell proliferation and differentiation as well as in memory-related tasks. However, whether these opposite effects are implicated in the pathogenesis of Alzheimer's disease (AD) remains unclear. Here, we find that ERα an...

2016
Barbara Nuvoli Andrea Sacconi Giancarlo Cortese Sabrina Germoni Bruno Murer Rossella Galati

This study aimed to investigate intratumoural estradiol and estrogen-receptors (ERα, ERβ and GPR30) in malignant pleural mesothelioma (MPM) to understand their function. Here, we report that immunohistochemistry of estradiol showed cytoplasmatic staining in 95% of fifty-seven human MPM samples with a trend toward a negative correlation between estradiol levels and the median post-diagnosis surv...

Journal: :American journal of physiology. Endocrinology and metabolism 2014
Alesha B Castillo Jason W Triplett Fredrick M Pavalko Charles H Turner

Mechanical loading is an important regulator in skeletal growth, maintenance, and aging. Estrogen receptors have a regulatory role in mechanically induced bone adaptation. Estrogen receptor-α (ERα) is known to enhance load-induced bone formation, whereas ERβ negatively regulates this process. We hypothesized that ERβ regulates mechanical signaling in osteoblasts. We tested this hypothesis by su...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Paul Mak Cheng Chang Bryan Pursell Arthur M Mercurio

Estrogen receptor β (ERβ) promotes the degradation of hypoxia inducible factor 1α (HIF-1α), which contributes to the ability of this hormone receptor to sustain the differentiation of epithelial and carcinoma cells. Although the loss of ERβ and consequent HIF-1 activation occur in prostate cancer with profound consequences, the mechanism by which ERβ promotes the degradation of HIF-1α is unknow...

Journal: :Cancer prevention research 2013
Abby D Benninghoff David E Williams

In the present study, the efficacy of indole-3-carbinol (I3C), a key bioactive component of cruciferous vegetables, for prevention of cancer in offspring exposed in utero to the environmental carcinogen dibenzo[def,p]chrysene (DBC) was evaluated using an estrogen receptor β (ERβ) knockout mouse model. I3C was provided either through the maternal diet coincident with carcinogen exposure during p...

Journal: :Investigative ophthalmology & visual science 2010
Anand Giddabasappa Matthew Bauler Muralimohan Yepuru Edward Chaum James T Dalton Jeetendra Eswaraka

PURPOSE To elucidate the mechanism of 17-β estradiol (17β-E(2))-mediated protection of retinal pigment epithelium (RPE) from oxidative stress. METHODS Cultured ARPE-19 cells were subjected to oxidative stress with t-butyl hydroxide or hydrogen peroxide in the presence or absence of 17β-E(2). Reactive oxygen species (ROS) were measured using H(2)DCFDA fluorescence. Apoptosis was evaluated by c...

Journal: :International Journal of Cancer 2021

Colorectal cancer (CRC) is the third leading cause of death in western world. In women, menopausal hormone therapy has been shown to reduce CRC incidence by 20%. Studies demonstrate that estrogen activating receptor beta (ERβ) protects against CRC. ERβ a nuclear regulates gene expression through interactions with chromatin. This molecular mechanism is, however, not well characterized colon. Her...

2016
Ying Xu Ting Chen Xin Li Ya-kun Qu Jin-na An Hong-xia Zheng Zi-jia Zhang Na Lin

Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in vitro studies focusing on the estrogen receptor (ER) pathway for further molec...

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