The signals that determine the correct polarity of breast epithelial structures in vivo are not understood. We have shown previously that luminal epithelial cells can be polarized when cultured within a reconstituted basement membrane gel. We reasoned that such cues in vivo may be given by myoepithelial cells. Accordingly, we used an assay where luminal epithelial cells are incorrectly polarize...

Matrix producing carcinoma of the breast is a unique subclass of metaplastic carcinoma, which is characterized by the existence of a ductal carcinomatous component with direct transition to areas showing cartilaginous or osseous differentiation lacking an interspersed spindle cell element. The tumor is of epithelial-myoepithelial histogenesis. It is said to carry a better prognosis compared to ...

Myoepithelial carcinomas are tumors arising from myoepithelial cells mainly or exclusively, they showed varied cell types and patterns leading to a wide range of differential diagnoses. Immunohistochemical analysis helped to determine the diagnosis. Recognition of myoepithelial carcinoma is clinically significant because, compared to its benign counterpart (myoepithelioma), It has increased fre...

Myoepithelial carcinoma, arising in a recurrent or in a pre-existing pleomorphic adenoma of the parotid gland is an extremely rare cancer. We herein report the case of myoepithelial carcinoma occurring in a recurrent pleomorphic adenoma, which showed a high metastatic potential. A 53-year-old male, who had undergone a superficial parotidectomy of the pleomorphic adenoma 2 years previously, pres...

The canonical view of the origin of tumor lymphovascular emboli is that they usually originate from lymphovascular invasion as part of a multistep metastatic process. Recent experimental evidence has suggested that metastasis can occur earlier than previously thought and we found evidence that tumor emboli formation can result from the short-circuiting step of encircling lymphovasculogenesis. E...

BACKGROUND The differential diagnosis of salivary carcinomas is always difficult and challenging. Salivary neoplasms often shows more than one growth pattern and significant morphologic variability may exist within a single tumor and between different tumors. The aim of this study was to examine the role of DOG1 (discovered on gastrointestinal tumor-1) and p63 immunohistochemistry in the diagno...

Epithelial and myoepithelial cells coexist in the rat R3230AC mammary tumor. To test the hypothesis that these two cell types constitute interactive but independent neoplastic populations, we obtained in vitro cell lines with epithelial or myoepithelial patterns and transplanted them in syngeneic animals. One stabilized line (EPI) and four cloned lines (A, C, D, E) with epithelial characteristi...