Glomerular development of the kidney was studied in newborn rats by electron microscopy. Four different stages of glomerular development were defined: vesicle fonnation, S-shaped body stage, capillary loop fonnation, and glomerular maturation. In the fust stage, the mesenchymal cells form a spheroid mass. This is followed by the S-shaped body stage in which clefts appear in the mass. Afte...

AbstractGene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. One promising form of gene delivery system (DDS) is liposomes. The success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. Liposomal gene delivery systems...

AbstractGene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. One promising form of gene delivery system (DDS) is liposomes. The success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. Liposomal gene delivery systems...

thermo-sensitive polymers were prepared by graft copolymerization of gelatin with n-isopropylacrylamide via gamma radiation. characterization of polymers such as dsc analysis, swelling in different ratios and cell assays were investigated. dsc and solubility analysis showed gelatin and nipaam monomer were grafted via gamma radiation successfully. results show swelling of samples increased with ...

Epithelial cell adhesion molecule 1 (EpCAM) is an epithelial membrane glycoprotein, often used as a surrogate pan-epithelial marker. To compare the expression patterns of EpCAM and pankeratin antibody (CKpan), gold standard detection, tissue microarrays containing 11,053 samples from 101 different tumor types were analysed by immunohistochemistry. staining was detectable in 99 (82.5%) 120 tumou...

Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovaria...

In this study, we examined the effect of a combination surface topographies (fiber alignments) and different stiffness poly(L-lactic acid) (PLLA) substrates on direct relationship between anti-cancer drug (CDDP) sensitivity for MDA-MB-231 cells mesenchymal properties under both normal hypoxic conditions. addition, studied induction epithelial–mesenchymal transition (EMT). The CDDP treatment hyp...

Epithelial myoepthial carcinoma (EMEC) is rare, low grad tumor with epithelial and myoepithelial components frequent local recurrence, also called glycogen rich adenoma (clear cell pattern), myoepithelioma (spindle plamocytiod patterns), (if only differentiation marked cytologic atypia). Occurs most frequently in the major salivary glands accounts for approximately 1% of all gland neoplasms tha...

Background: Epithelial cell adhesion molecule (EpCAM) is one of the most commonly used markers cancer stem cells (CSCs). However, diagnostic and prognostic significance EpCAM in lung remains largely undetermined. In present study, we systematically summarized elucidated correlation between overexpression through a meta-analysis.

Abstract Purpose The importance of mechanical forces and microenvironment in guiding cellular behavior has been widely accepted. Together with the extracellular matrix (ECM), epithelial cells form a highly connected system subjected to various cues from their environment, such as ECM stiffness, tensile compressive forces. stiffness linked many pathologies, including tumor formation. However, ou...