This book is an ideal way for clinicians and researchers in epileptology to update themselves about current concepts and knowledge of pathophysiological seizure generation mechanisms and ongoing developments in seizure prediction strategies. The book especially highlights the importance of multidisciplinary teamwork involving experts in the neurosciences, mathematics, physics, and engineering (...

The First International Collaborative Workshop on Seizure Prediction was held at the Department of Epileptology, University of Bonn, in Bonn, Germany on April 24-28, 2002. Organized by the Universities of Pennsylvania and Bonn, and funded by grants from the American Epilepsy Society, the German Section of the International League against Epilepsy, and the German Section of the International Fed...

The role of the substantia nigra pars reticulata (SNPr) and superior colliculus (SC) network in rat strains susceptible to audiogenic seizures still remain underexplored in epileptology. In a previous study from our laboratory, the GABAergic drugs bicuculline (BIC) and muscimol (MUS) were microinjected into the deep layers of either the anterior SC (aSC) or the posterior SC (pSC) in animals of ...

Epilepsy constitutes a heterogeneous group of disorders that is characterized by recurrent unprovoked seizures due to widely different etiologies. Multidrug resistance remains a major issue in clinical epileptology, where one third of patients with epilepsy continue to have seizures. Role of efflux transporters in multidrug resistant epilepsy has been attributed to drug-resistant epilepsy altho...

OBJECTIVE An important issue in epileptology is the question whether information extracted from the EEG of epilepsy patients can be used for the prediction of seizures. Several studies have claimed evidence for the existence of a pre-seizure state that can be detected using different characterizing measures. In this paper, we evaluate the predictability of seizures by comparing the predictive p...

I am not a member of the medical community, but an epileptic man having completed a book manuscript discussing the state of epileptology from the perspective of a patient. While researching topics, I have read numerous articles from Seizure. In the process of doing so, I have become disillusioned by the stigmatization that I have felt in the endeavor. I refer to the habit of many of your contri...

BACKGROUND Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac complications. Our goal was to assess the nature and frequency of complications occurring in association with GTCS. METHODS We retrospectively extracted data from emergency protoc...

Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults. British Infection Working Party. Review. J Infect 1999;39:1–15. 6 Whitley RJ, Gnann JW. Viral encephalitis: familiar infections and emerging pathogens. Review. Lancet 2002;359:507–13. 7 Friedman DI, Jacobson DM. Diagnostic criteria for idiopathic intracranial hypert...

Many studies have focused on the nonlinear analysis of electroencephalography (EEG) mainly for the characterization of epileptic brain states. It is assumed that at least two states of the epileptic brain are possible: the interictal state characterized by a normal apparently random, steady-state EEG ongoing activity; and the ictal state that is characterized by paroxysmal occurrence of synchro...

Prevalence of epilepsy in developing countries is considered to be 2 to 5 times superior to the industrialized countries. In tropical areas, the diagnosis of epilepsy is still reliant on the clinic and requires a precise semiological description. A good epidemiological and clinical research requires standardized and validated screening tools. The objective of this work was to evaluate the valid...