Background: Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is produced by different tissues, including the endometrium and ovary. VEGF is involved in many processes related to reproductive physiology, including angiogenesis, which is essential for implantation and placentation. It has been suggested that VEGF may be the angiogenic factor responsible for the implan...

Background: Toll-like receptors (TLRs) form the major family of pattern recognition receptors (PRRs) which are involved in the innate immunity. They recognize pathogen-associated molecular patterns (PAMPs) in bacteria, viruses, fungi and parasites. In human, 10 members of this family have been identified so far. Among these TLRs, TLR3, 7, 8 and 9 designed to recognize nucleic acids and expresse...

Background: The presence of immune system within the female reproductive tract is increasingly being recognized as an important element for maintaining host protection and promoting reproductive functions. The Toll-Like Receptors (TLRs) family plays an important role in innate immune responses against microbial pathogens within the genital tract. These receptors recognize distinct pathogen-asso...

ectopic pregnancy (ep) is a potentially life-threatening condition in which the embryo implants outside the uterine endometrial cavity. abdominal pregnancy is an atypical site wherein the product of conception lies totally outside the reproductive tract. primary abdominal pregnancy is a very rare condition with a high mortality rate. diagnosis is often late or misdiagnosed. the aim of introduci...

Prostaglandin (PG)E derivatives are widely used for treating gastric mucosal injury. PGE receptors are classified into four subtypes, EP(1), EP(2), EP(3), and EP(4). We have tested which EP receptor subtypes participate in gastric mucosal protection against ethanol-induced gastric mucosal injury and clarified the mechanisms of such protection. The gastric mucosa of anesthetized rats was perfuse...

objective: to evaluate the importance of cytokine type in embryo implantation in uterus specified and activated macrophages interfere the tube movements and embryo retention in uterine tubes by smooth muscle relaxation and disrupting ciliary function. therefore, increased risk of infection with hp during pregnancy, we investigated relation between helicobacter pylori (hp) infection and prevalen...

background & aim: this experiment was conducted to examine the effect of different levels of echinacea purpurea (ep) in comparison with an antibiotic (flavofosfolipol) on total antioxidant activity (aoa) in serum of broiler chicks. experimental: in this trial 240 one-day-old broiler chicks (ross 308) were weighed and randomly assigned to the 5 treatment groups, each with 4 replicates with 1...

BACKGROUND Prostaglandin E(2) (PGE(2)) is important in ductus arteriosus (DA) patency, but the types of functional PGE(2) receptors (EP) in the developing DA are not known. We postulated that age-dependent alterations in EP and/or their subtypes may possibly contribute to the reduced responsiveness of the newborn DA to PGE(2). METHODS AND RESULTS We determined PGE(2) receptor subtypes by comp...

Ethyl pyruvate (EP), a derivative of pyruvic acid, is known to have protective effects against ischemic cardiomyopathy and other disorders. However, little is known about its role in Adriamycin (ADR)-induced cardiomyopathy. The present study was designed to investigate the impact of EP on ADR-induced cardiomyopathy in an animal model. Sixty male Sprague-Dawley (SD) rats were divided into four g...

We have reported previously that PGE(2) inhibits dendritic cells (DC) functions. Because E prostanoid receptor (EPR) subtypes involved in this action are unknown, expression and functions of these receptors were examined in DC. Western blot and flow cytometry analyses showed that all EPRs were coexpressed in DC. In a dose-dependent manner, lipopolysaccharide (LPS) enhanced EP(2)R/EP(4)R but not...