The interaction between bovine serum albumin (BSA) and methyl cinnamate (MC), an strawberry flavor compound, was investigated. We found that BSA and MC form complex with stoichiometry (n) equal 1, driven by system’s entropy increase and enthalpy reduce at pH 7.4, 5.0 and 3.5, with binding constants (Kb) in magnitude of 10 5 L.mol -1 . There was difference in variation of standard enthalpy of co...

Detailed thermodynamic analysis of fragment binding revealed that unlike drug-like compounds, fragments bind with significant enthalpic preference. This observation is in line with the size dependency of binding enthalpy contributions and is also supported by a large body of experimental data from direct binding thermodynamic measurements. The enthalpy-driven binding of fragments represents a t...

For the current exploration programs high enthalpy landing missions are foreseen. It is rather difficult to simulate the corresponding enthalpies with steady state facilities. For the case of sample return missions such as Genesis, STARDUST or Hayabusa hyperbolic entries require maximum enthalpies of about 80 MJ/kg. Atmospheric entry parameters of relevance were derived with the model of Allan ...

A. H. Treiman, J. Gross, M. J. Kulis, and A. F. Glazner. Lunar and Planetary Institute, 3600 Bay Area Blvd., Houston TX 77058 [email protected]. Department of Earth and Planetary Sciences, Rutgers University, 610 Taylor Rd., Piscataway NJ 08854, [email protected]. Extreme Environments Laboratory, NASA Glenn Research Center, 2100 Brookpark Road Cleveland, OH 44135, [email protected]...

The energetics of ATP’ hydrolysis to ADP and P have been studied previously by combining either thermal (1, 2) or free energy (3-6) data for a number of chemical reactions according to the usual procedures of chemical thermodynamics. Such calculations, however, suffer from the fact that the uncertainties in each measurement are compounded in the final result. The ATPase properties of myosin off...

We review recent advances in the methodology of pulsed time-resolved photoacoustics and its application to studies of photosynthetic reaction centers and membrane receptors such as the G protein-coupled receptor rhodopsin. The experimental parameters accessible to photoacoustics include molecular volume change and photoreaction enthalpy change. Light-driven volume change secondary to protein co...

This article is concerned with the formulation and numerical solution of equations for modelling multicomponent, two-phase, thermal fluid flow in porous media. The fluid model consists of individual chemical component (species) conservation equations, Darcy’s law for volumetric flow rates and an energy equation in terms of enthalpy. The model is closed with an equation of state and phase equili...

Viscosity and enthalpy relaxation from the amorphous state into the supercooled liquid state was investigated in the bulk metallic glass forming Zr46.75Ti8.25Cu7.5Ni10Be27.5 alloy below the calorimetric glass transition. At different temperatures, the viscosities relax into states that obey the same Vogel–Fulcher–Tammann relation as the data obtained at higher temperatures in the supercooled li...

A drug molecule should bind to its target with high affinity and selectivity. Because the binding affinity is a combined function of the binding enthalpy and the binding entropy, extremely high affinity requires that both terms contribute favorably to binding. The binding enthalpy, however, is notoriously more difficult to optimize than the binding entropy, a fact that has resulted in thermodyn...

The kinetics and thermodynamics of berberine inclusion in cucurbit[7]uril was studied by stopped-flow method, fluorescence titrations, and isothermal calorimetry in neat water. The ~500-fold fluorescence intensity enhancement upon encapsulation was exploited to monitor the complex formation in real time at various temperatures. The increase in the fluorescence intensity could be fitted well by ...