نتایج جستجو برای: enteric glial cells
تعداد نتایج: 1403854 فیلتر نتایج به سال:
background and objective: gliomas are the most common primary brain tumors. despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. cd117, the gene product of c-kit has been expressed in cells of glial tumors. because gastrointestinal stromal tumors (gists) that express cd117 respond dramatically to treatment with tyrosine kinase inhibitors, identif...
Introduction: The nerve fibers in central nervous system are surrounded by myelin sheet which is formed by oligodendrocytes. Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available s...
Most of the physiological information on the enteric nervous system has been obtained from studies on preparations of the myenteric ganglia attached to the longitudinal muscle layer. This preparation has a number of disadvantages, e.g., the inability to make patch-clamp recordings and the occurrence of muscle movements. To overcome these limitations we used isolated myenteric ganglia from the g...
According to current dogma, there is little or no ongoing neurogenesis in the fully developed adult enteric nervous system. This lack of neurogenesis leaves unanswered the question of how enteric neuronal populations are maintained in adult guts, given previous reports of ongoing neuronal death. Here, we confirm that despite ongoing neuronal cell loss because of apoptosis in the myenteric gangl...
objective: embryonic cerebrospinal fluid (e-csf) has an important role in development of embryonic and adult brain. proteomic analysis suggests that this fluid has many morphogenes and cytokines that alter in time and space throughout embryonic life. the aim of this study was to evaluate the developmental effect of embryonic csf on proliferation and differentiation of neuroprogenitor cells in d...
Mutations in the Neuroligin-3 (Nlgn3) gene are implicated autism spectrum disorder (ASD) and gastrointestinal (GI) dysfunction, but cellular Nlgn3 expression enteric nervous system remains to be characterised. We combined RNAScope situ hybridization immunofluorescence measure mRNA cholinergic VIP-expressing submucosal neurons, nitrergic calretinin-containing myenteric neurons glial cells both W...
Early pathological manifestations of Crohn's disease (CD) include vascular disruption, T cell infiltration of nerve plexi, neuronal degeneration, and induction of T helper 1 cytokine responses. This study demonstrates that disruption of the enteric glial cell network in CD patients represents another early pathological feature that may be modeled after CD8(+) T cell-mediated autoimmune targetin...
The enteric nervous system (ENS) situated within the gastrointestinal tract comprises an intricate network of neurons and glia which together regulate intestinal function. The exact neuro-glial circuitry and the signaling molecules involved are yet to be fully elucidated. Vasoactive intestinal peptide (VIP) is one of the main neurotransmitters in the gut, and is important for regulating intesti...
Glial-derived neurotrophic factor (Gdnf) is required for morphogenesis of the enteric nervous system (ENS) and it has been shown to regulate proliferation, differentiation, and survival of cultured enteric neural crest-derived cells (ENCCs). The goal of this study was to investigate its in vivo role in the colon, the site most commonly affected by intestinal neuropathies such as Hirschsprung's ...
OBJECTIVES Enteric neuropathies are severe gastrointestinal disorders with unsatisfactory outcomes. We aimed to investigate the potential of enteric neural stem cell therapy approaches for such disorders by transplanting mouse enteric neural crest cells (ENCCs) into ganglionic and aganglionic mouse gut in vivo and analysing functional integration and long-term safety. DESIGN Neurospheres gene...
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