نتایج جستجو برای: enos protein

تعداد نتایج: 1236383  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Takahisa Murata Kazuya Kinoshita Masatoshi Hori Masayoshi Kuwahara Hirokazu Tsubone Hideaki Karaki Hiroshi Ozaki

OBJECTIVE We investigated the effects of fluvastatin on hypoxia-induced (1 to 3 weeks, 10% O2) pulmonary hypertension with focus on endothelial nitric oxide synthase (eNOS) activity. METHODS AND RESULTS Oral fluvastatin treatment (1 mg/kg daily) prevented the causing and progression of pulmonary hypertension as determined by the right ventricular pressure, right ventricular hypertrophy, and m...

Journal: :American journal of physiology. Heart and circulatory physiology 2010
Changyi Chen Jun Jiang Jian-Ming Lü Hong Chai Xinwen Wang Peter H Lin Qizhi Yao

Resistin is a newly discovered adipocyte-derived cytokine that may play an important role in insulin resistance, diabetes, adipogenesis, inflammation, and cardiovascular disease. However, it is largely unknown whether resistin impairs endothelial functions by affecting the endothelial nitric oxide synthase (eNOS) system. In this study, we determined the effect of human recombinant resistin prot...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Yang-Ming Yang An Huang Gabor Kaley Dong Sun

Endothelial nitric oxide synthase (eNOS) uncoupling is a mechanism that leads to endothelial dysfunction. Previously, we reported that shear stress-induced release of nitric oxide in vessels of aged rats was significantly reduced and was accompanied by increased production of superoxide (18, 27). In the present study, we investigated the influence of aging on eNOS uncoupling. Mesenteric arterie...

Journal: :Circulation 2003
Huige Li Christian Burkhardt Ulf-Rüdiger Heinrich Isolde Brausch Ning Xia Ulrich Förstermann

BACKGROUND Histamine has a short-term, transient, stimulating effect on endothelial nitric oxide synthase (eNOS) activity; however, long-term effects on eNOS have not been described yet. In addition, the vascular effect of histamine seems to depend critically on eNOS functionality. Therefore, we studied the effects of histamine on eNOS gene expression and function. METHODS AND RESULTS In huma...

Journal: :Journal of the American Society of Nephrology : JASN 2004
Keiko Sato Minoru Kihara Tatsuo Hashimoto Kei Matsushita Yu-Ichi Koide Koichi Tamura Nobuhito Hirawa Yoshiyuki Toya Akiyoshi Fukamizu Satoshi Umemura

The effects of altered dietary salt intake and/or hydralazine-induced hypotension on renal endothelial nitric oxide synthase (eNOS) expression were determined in angiotensin type-1a receptor gene knockout (At1a-/-) and wild-type (At1a+/+) mice. In At1a-/- mice, the levels of renal cortical eNOS mRNA and protein were 5 times and 3.5 times higher, respectively, in the high-salt (4% NaCl) group th...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2000
V Shah A F Chen S Cao H Hendrickson D Weiler L Smith J Yao Z S Katusic

Endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) contributes to hepatic vascular homeostasis. The aim of this study was to examine whether delivery of an adenoviral vector encoding eNOS gene to liver affects vasomotor function in vivo and the mechanism of NO production in vitro. Rats were administered adenoviruses encoding beta-galactosidase (AdCMVLacZ) or eNOS (AdCMVeNOS) via...

Journal: :The Journal of Cell Biology 1997
Jianwei Liu Thomas E. Hughes William C. Sessa

Catalytically active endothelial nitric oxide synthase (eNOS) is located on the Golgi complex and in the caveolae of endothelial cells (EC). Mislocalization of eNOS caused by mutation of the N-myristoylation or cysteine palmitoylation sites impairs production of stimulated nitric oxide (NO), suggesting that intracellular targeting is critical for optimal NO production. To investigate the molecu...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2014
Feng Wu William S Szczepaniak Sruti Shiva Huanbo Liu Yinna Wang Ling Wang Ying Wang Eric E Kelley Alex F Chen Mark T Gladwin Bryan J McVerry

Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by enzymatic modification, eNOS may become uncoupled, producing superoxide in lieu of NO. This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial bar...

Journal: :Archives of disease in childhood. Fetal and neonatal edition 1998
B O Okoye P D Losty M J Fisher I Wilmott D A Lloyd

AIMS To study the effect of prenatal glucocorticoid treatment on endothelial nitric oxide synthase (eNOS) expression in rats with congenital diaphragmatic hernia (CDH). METHODS CDH was induced in fetal rats by the maternal administration of nitrofen on day 9.5 of gestation. Dexamethasone was administered on days 18.5 and 19.5 before delivery of the fetuses on days 20.5 and 21.5. Pulmonary eNO...

Journal: :WebmedCentral 2010
Esther Koai Tibisay Rincon Rios John Edwards

Although it is known that VEGF increases eNOS protein, the mechanisms responsible remain unclear. To determine if VEGF alters eNOS transcription, human umbilical vein endothelial cells were transfected with reporters under the control of the eNOS promoter and stimulated with VEGF165. VEGF significantly increased eNOS-mRNA after 2 hours exposure. VEGF significantly increased eNOS reporter activi...

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