Engineering design and analysis (EDA) software circuit simulators has traditionally focussed virtually exclusively on the scientific calculations performed by the software. Software technology, however, has matured to the point where it can provide significant improvements in the ability of EDA software to address the full requirement of the engineering design flow. In this paper we describe so...

The development of ectodermal organs requires signalling by ectodysplasin (Eda), a tumor necrosis factor (TNF) family member, its receptor Edar and downstream activation of the nuclear factor kappaB (NF-kappaB) transcription factor. In humans, mutations in the Eda pathway components cause hypohidrotic ectodermal dysplasia, a syndrome characterized by missing teeth, sparse hair and defects in sw...

OBJECTIVE Cellular fibronectin containing extra domain A (EDA(+)-FN) is abundant in the arteries of patients with atherosclerosis. Several in vitro studies suggest that EDA(+)-FN interacts with Toll-like receptor 4 (TLR4). We tested the hypothesis that EDA(+)-FN exacerbates atherosclerosis through TLR4 in a clinically relevant model of atherosclerosis, the apolipoprotein E-deficient (Apoe(-/-))...

Cellular fibronectin containing extra domain A (Fn-EDA+), which is produced in response to tissue injury in several disease states, has prothrombotic activity and is known to interact with Toll-like-receptor 4 (TLR4). The underlying mechanism and cell types involved in mediating the prothrombotic effect of Fn-EDA+ still remain unknown. Using intravital microscopy, we evaluated susceptibility to...

abstract in this paper,using a structural decomposition analysis (sda) and the latest available input-output tables we investigate the sources of labor productivity growth in norway, south korea and iran. then, the contribution of each source in the growth of labor productivity is discussed. the results show that among six factors, value added coefficient is the most influencing factoracross al...

Most of the microelectronic circuits fabricated today are synchronous, i.e. they are driven by one or several clock signals. Synchronous circuit design faces several fundamental challenges such as high-speed clock distribution, integration of multiple cores operating at different clock rates, reduction of power consumption and dealing with voltage, temperature, manufacturing and runtime variati...

Gelman’s article is a thought-provoking mix of opinions and creative methodology. I agree with Gelman that the disjunction of models and exploratory data analysis (EDA) in mainstream statistics is unsound. The assumption that models belong exclusively to confirmatory data analysis (CDA) is easily shown to be wrong in practice. Many uses of models, in particular model selection, are exploratory,...

OBJECTIVE Fibronectin (FN) plays an important role in the formation of stable arterial thrombi at the site of vascular injury. FN containing Extra Domain A (EDA+ FN) is absent from normal plasma, but elevated plasma levels of EDA+ FN are found in several pathological conditions. We hypothesized that EDA+ FN plays a special role in thrombosis. METHODS AND RESULTS We used mouse strains constitu...

the main goal of this study is to identify the determinants of the energy intensity in the iranian economy using annual data for the period 1974-2012. changes in energy intensity can be seen as related to three factors including price, income, and autonomous energy efficiency improvements (based on technical progress). moreover the role of energy quality in enhancement of total factor productiv...