Hormone replacement therapy may increase the quality of life of postmenopausal women. Any regimen need to offer long-term endometrial safety. It is a standard to consider the co-administration of a sequential progestogen when estrogen replacement should be initiated in non-hysterectomized women. It is almost impossible to decide which combination of an estrogen and a progestogen seems to be opt...

Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...

Introduction Swiss incidences as well as mortality rates for cancer of the corpus uteri have decreased slightly over the last 20 years [1]. In the recent past (2006-2010), about 16 in 100’000 women were diagnosed each year with endometrial cancer, while 3 in 100’000 died of their disease. The most common type of cancer is adenocarcinoma of the endometrial lining, which is the most common malign...

BACKGROUND Inhibins are important regulators of the female reproductive system. Recently, two new inhibin subunits betaC and betaE have been described, although it is unclear if they are synthesized in normal human endometrium. METHODS Samples of human endometrium were obtained from 82 premenopausal, non-pregnant patients undergoing gynecological surgery for benign diseases. Endometrium sampl...

The recently identified trans-membrane G protein-coupled estrogen receptor 1 (GPER, GPR30) has been implicated in rapid non-genomic effects of estrogens. This focuses on expression and localization of GPER mRNA and protein in normal cyclic endometrium and early pregnancy decidua. Real-time PCR, western blotting, in situ hybridization and immuno-histochemistry were used. Endometrial expression o...

background: toll-like receptor (tlr)-mediated inflammatory processes are supposed to be involved in pathophysiology of spontaneous abortion and preterm labor. here, we investigated functional responses of human endometrial stromal cells (escs) and whole endometrial cells (wecs) to lipopolysaccharide (lps) and lipoteichoic acid (lta). methods: endometrial tissues were obtained from 15 cycling wo...