نتایج جستجو برای: endocannabinoid

تعداد نتایج: 3595  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Motokazu Uchigashima Madoka Narushima Masahiro Fukaya Istvan Katona Masanobu Kano Masahiko Watanabe

Endogenous cannabinoids (endocannabinoids) mediate retrograde signals for short- and long-term suppression of transmitter release at synapses of striatal medium spiny (MS) neurons. An endocannabinoid, 2-arachidonoyl-glycerol (2-AG), is synthesized from diacylglycerol (DAG) after membrane depolarization and Gq-coupled receptor activation. To understand 2-AG-mediated retrograde signaling in the s...

2016
Marta Rubio Sara Valdeolivas Fabiana Piscitelli Roberta Verde Valentina Satta Eva Barroso Marisol Montolio Luis Miguel Aras Vincenzo Di Marzo Onintza Sagredo Javier Fernández‐Ruiz

Cannabidiol (CBD) reduces seizures in childhood epilepsy syndromes including Dravet syndrome (DS). A formulation of CBD has obtained orphan drug designation for these syndromes and clinical trials are currently underway. The mechanism responsible for CBD effects is not known, although it could involve targets sensitive to CBD in other neurological disorders. We believe of interest to investigat...

Journal: :Cardiovascular research 2009
Li-sheng Jiang Jun Pu Zhi-hua Han Liu-hua Hu Ben He

AIMS Evidence from recent studies suggests that the endocannabinoid system participates in the regulation of lipid metabolism and body composition. We hypothesize that the system is activated by oxidized low-density lipoprotein (oxLDL) and regulates cellular cholesterol metabolism in macrophages. METHODS AND RESULTS Primary peritoneal macrophages isolated from Sprague-Dawley rats and RAW264.7...

2012
Alexandros G. Sykaras Claire Demenis R. Maynard Case John T. McLaughlin Craig P. Smith

Enteroendocrine cells have a critical role in regulation of appetite and energy balance. I-cells are a subtype of enteroendocrine cells localized in duodenum that release cholecystokinin in response to ingested fat and amino-acids. Despite their potentially pivotal role in nutrient sensing and feeding behaviour, native I-cells have previously been difficult to isolate and study. Here we describ...

Journal: :Journal of applied toxicology : JAT 2013
Panagiotis Zogopoulos Ioanna Vasileiou Efstratios Patsouris Stamatios Theocharis

Considerable progress has been made, recently, in understanding the role of the endocannabinoid system in regard to neuroprotection. Endogenous cannabinoids have received increasing attention as potential protective agents in several cases of neuronal injury. The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids) and proteins ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001
D Baker G Pryce J L Croxford P Brown R G Pertwee A Makriyannis A Khanolkar L Layward F Fezza T Bisogno V Di Marzo

Spasticity is a complicating sign in multiple sclerosis that also develops in a model of chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice. In areas associated with nerve damage, increased levels of the endocannabinoids, anandamide (arachidonoylethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG), and of the AEA congener, palmitoylethanolamide (PEA), were detected her...

2017
Gábor Nagy-Grócz Ferenc Zádor Szabolcs Dvorácskó Zsuzsanna Bohár Sándor Benyhe Csaba Tömböly Árpád Párdutz László Vécsei

Both the kynurenine and the endocannabinoid systems are involved in several neurological disorders, such as migraine and there are increasing number of reports demonstrating that there are interactions of two systems. Although their cooperation has not yet been implicated in migraine, there are reports suggesting this possibility. Additionally, the individual role of the endocannabinoid and kyn...

2017
Carmen Rodríguez-Cueto Mariluz Hernández-Gálvez Cecilia J Hillard Patricia Maciel Sara Valdeolivas José A Ramos María Gómez-Ruiz Javier Fernández-Ruiz

Spinocerebellar ataxia type-3 (SCA-3) is the most prevalent autosomal dominant inherited ataxia. We recently found that the endocannabinoid system is altered in the post-mortem cerebellum of SCA-3 patients, and similar results were also found in the cerebellar and brainstem nuclei of a SCA-3 transgenic mouse model. Given that the neuropathology of SCA-3 is not restricted to these two brain regi...

Journal: :Journal of neuroendocrinology 2008
E Fride

The endocannabinoid system, including its receptors (CB(1) and CB(2)), endogenous ligands ('endocannabinoids'), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic development and throughout pre- and postnatal development. In addition, the endocannabinoids, notably 2-arachidonyl glycerol, are also present in maternal milk...

2017
María Teresa Ramírez-López Mariam Vázquez Ermelinda Lomazzo Clementine Hofmann Rosario Noemi Blanco Francisco Alén María Antón Juan Decara Rocío Arco Laura Orio Juan Suárez Beat Lutz Raquel Gómez de Heras Laura Bindila Fernando Rodríguez de Fonseca

Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and ...

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