Among the many proteins used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymerases, Pol λ and Pol µ. Which of these two polymerases is preferentially used for filling DNA gaps during NHEJ partly depends on sequence complementarity at the break, with Pol λ and Pol µ repairing complementary and noncomplementary ends, respectively. To bette...

Background: Aim of the study was to evaluate sealing ability of five different root end filling materials by dye penetration method. Materials and Methods: About 100 extracted maxillary central incisors were sectioned at Cementoenamel junction. Access cavities were prepared, instrumented chemo-mechanically, and obturated with laterally condensed gutta-percha and AH Plus sealer. Access cavities ...

GIC, microleakage, Miracle Mix, MTA, root-end filling. Abstract The main objective of a root end filling material is to provide an apical seal that prevents the movement of bacteria and the diffusion of bacterial products from the root canal system into periapical tissues. The aim of this study was to compare the microleakage of three root end filling materials Mineral trioxide aggregate (MTA),...

Whereas improvement in diastolic function indexes in response to therapeutic interventions has been attributed to a beneficial effect of the intervention, measurements of diastolic function appear to be influenced by changes in loading conditions, heart rate and sympathetic tone. To determine the effect of body position and short-term pharmacologic intervention on radionuclide angiographically ...

Left ventricular systolic function does not correlate well with functional class in patients with dilated cardiomyopathy. To determine whether the correlation is better with Doppler indexes of left ventricular diastolic function, 34 patients with dilated cardiomyopathy (M-mode echocardiographic end-diastolic dimension greater than 60 mm, fractional shortening less than 25%, increased E point-se...

Although the pericardium can exert a restraining effect on filling of the normal left ventricle, it is uncertain to what extent the pericardium influences left ventricular filling during chronic volume overload. We measured left and right ventricular pressure and left ventricular segment dimension before and after pericardiectomy over a range of left ventricular end-diastolic pressure from <5 t...

Although the pericardium can exert a restraining effect on filling of the normal left ventricle, it is uncertain to what extent the pericardium influences left ventricular filling during chronic volume overload. We measured left and right ventricular pressure and left ventricular segment dimension before and after pericardiectomy over a range of left ventricular end-diastolic pressure from <5 t...