نتایج جستجو برای: emulsion solvent diffusion method
تعداد نتایج: 1812619 فیلتر نتایج به سال:
Purpose: The purpose of this work was to develop a prolonged microsponge drug delivery system containing dicyclomine. Methods: Dicyclomine-loaded, Eudragit-based microsponges were prepared using a quasi-emulsion solvent diffusion method. The compatibility of the drug with formulation components was established by differential scanning calorimetry (DSC) and Fourier transform infra-red (FTIR). Pr...
The World Health Organization (WHO) has reported that globally 235 million people suffer from chronic and other inflammatory diseases. The short half-lives of nonsteroidal anti-inflammatory drugs (NSAIDs) and their notoriety in causing gastrointestinal discomforts, warrants these drugs to be released in a controlled and sustained manner. Although polymeric particles have been widely used for dr...
Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...
Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug delivery strategies using ultrasound. [(18) F]fluorodeoxyglucose (FDG) was encapsulat...
The aim of the present study was to develop and evaluate microsponge based topical delivery system of acyclovir for sustained and enhanced drug deposition in the skin. Microsponges containing acyclovir were prepared by an emulsion solvent diffusion method. The effect of formulation variable such as drug: polymer ratio, stirring speed, internal phase on the physical characteristics of microspong...
We present a modulated gradient spin-echo method (MGSE), which uses a train of sinusoidally shaped gradient pulses separated by 180-degree RF pulses. The RF pulses efficiently refocus chemical shifts and de-phasing due to susceptibility differences, resulting in undistorted, high-resolution diffusion weighted spectra. This allows for simultaneous spectral characterization of diffusion of severa...
The present study was aimed to develop and optimize the microsponges of curcumin for colon specific drug delivery in a view to bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method using 3(2) full factorial design. Prepared microsponges were optimized in order to analyze the effects of independent va...
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