Pulmonary diffusing capacity and arterial blood Po(2) decrease in humans when 10% fat emulsion is infused. To study its effects on the pulmonary circulation and lung fluid balance, we infused 0.25 g/kg x h of a 10% fat emulsion (Intralipid, Cutter Laboratories, Inc., Berkeley, Calif.) into an awake sheep lung lymph preparation. The emulsion caused a sustained increase in pulmonary artery pressu...

Emulsions are a central component of many modern formulations in food, pharmaceuticals, agrichemicals and personal care products. The droplets in these formulations are limited to being spherical as a consequence of the interfacial tension between the dispersed phase and continuous phase. The ability to control emulsion droplet morphology and stabilize non-spherical droplets would enable the mo...

BACKGROUND Toxicity of calcium channel blockers leads to high patient mortality and there is no effective antidote. The benefit of using 20% lipid emulsion and sugammadex has been reported. The present study measured the effect of sugammadex and 20% lipid emulsion on hemodynamics and survival in a rat model of verapamil toxicity. MATERIAL/METHODS In this single-blinded randomized control stud...

The goal of this in vitro study was to examine the effect of a lipid emulsion on toxic-dose bupivacaine-induced vasodilation in a model of tyrosine phosphatase inhibitor sodium orthovanadate-induced contraction in endothelium-denuded rat aortae and to elucidate the associated cellular mechanism. The effect of a lipid emulsion on vasodilation induced by a toxic dose of a local anesthetic during ...

This study investigated the effects of microbial transglutaminase (MTGase) and pH-shift processing on the functional properties of porcine myofibrillar proteins (MP). The pH-shift processing was carried out by decreasing the pH of MP suspension to 3.0, followed by re-adjustment to pH 6.2. The native (CM) and pH-shifted MP (PM) was reacted with and without MTGase, and the gelling and emulsion ch...

Three commercial silicone emulsions with different functional groups i.e., quat-silicone micro-emulsion (<40 nm particle size), amino-silicone macro-emulsion (110 nm), and silicone macro-emulsion with alkylmodified side groups (740 nm) were used to protect wood samples against fungal decay. The addition of the emulsions to an agar growth medium revealed that all three silicone formulations inhi...

triptoreline is a potent agonist of luteinizing hormone-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. frequent injection of drug decreases patients’ compliance. the present study describes the formulation of a sustained release microparticulate drug delivery system containing triptoreline acetate, using poly (d,l lacti...

objective(s): the increasing use of methamphetamine (meth) in the last decades has made it the second most abused drug. advancs in the area of intravenous lipid emulsion (ile) have led to its potential application in the treatment of poisoning. the present study aims to investigate the potential role of ile as an antidote for acute meth poisoning. materials and methods: two groups of six male r...

results the results showed that the maximum oil was incorporated in microemulsion system that contained surfactant to cosurfactant ratio of 4:1. the mean droplet size range of microemulsion formulation was in the range of 5.09 to 159 nm, and its refractory index (ri) and ph were 1.44 and 7, respectively. viscosity range was 57-226 cps. drug release profile showed that 48.18% of the drug release...