1. Kimura K, Suzuki S, Wachino J et al. First molecular characterization of group B streptococci with reduced penicillin susceptibility. Antimicrob Agents Chemother 2008; 52: 2890–7. 2. Nagano N, Nagano Y, Kimura K et al. Genetic heterogeneity in pbp genes among clinically isolated group B streptococci with reduced penicillin susceptibility. Antimicrob Agents Chemother 2008; 52: 4258–67. 3. Jon...

1. Professor of Respiratory Medicine, University of Oxford, Honorary Consultant Physician, University of Oxford Hospitals NHS Trust, Oxford, UK 2. Professor of Medicine, Head of the Pulmonary Department, Mainz University Hospital, Mainz, Germany 3. Associate Professor of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland 4. Asthmas and Airway Translational Research Unit, Washington...

Let G be a complex reductive group, V a G-module and f ∈ O(V )G a nonconstant homogeneous invariant. We investigate relations between the following properties: • df : V → V ∗ is dominant, • f is homaloidal, i.e., df induces a birational map P(V ) → P(V ∗), • V is stable, i.e., the generic G-orbit is closed. If f generates O(V )G, we show that the properties are equivalent, generalizing results ...

An analysis of the Kimura 3ST model of DNA sequence evolution is given on the basis of its continuous Lie symmetries. The rate matrix commutes with a U(1)×U(1)×U(1) phase subgroup of the group GL(4) of 4× 4 invertible complex matrices acting on a linear space spanned by the 4 nucleic acid base letters. The diagonal ‘branching operator’ representing speciation is defined, and shown to intertwine...

Evolution by compensatory mutations is accelerated by gene duplication because selective constraint is relaxed by gene redundancy. A mutation is called compensatory if it corrects the effect of an earlier deleterious mutation. Without duplication, Kimura has shown that the time for spreading of compensatory mutations is much reduced by tight linkage between the two chromosomal sites of mutation...

Kimura disease is a rare chronic inflammatory disease of unknown etiology. The disease typically presents in young Asian males with single or multiple slowly progressing painless subcutaneous lumps in the head and neck region; regional lymphadenopathy is commonly accompanied. The disease is associated with peripheral blood eosinophilia and elevated serum immunoglobulin E levels. This gives an i...

We give a review of Chen-Ruan orbifold cohomology (and its cousin stringy cohomology) but starting with a reformulation, due to JarvisKaufmann-Kimura, which simplifies the original definitions and proofs by removing any reference to complex curves. We explain the relationship between the two approaches and describe their connection to other areas.