Electrocution is a death caused by an application of electrical current to the human body. Our present understanding electrocution—as induction ventricular fibrillation (VF)—followed nearly century-long path misunderstandings and speculation primarily focused on hypotheses asphyxia as well central nervous system trauma. It hard for us today appreciate past mystery unexpected sudden usually bere...

as a homogeneous disease entity within the schizophrenia syndrome. Utilizing the Schedule for the Deficit Syndrome (SDS) has allowed the definition of a subgroup dominated by persistent clusters of negative symptoms. While a number of studies have appeared over the years examining the electrophysiological correlates of the cluster of negative symptoms in schizophrenia, only a few studies have a...

In this paper, we illustrate how advanced computational modelling and simulation can be used to investigate drug-induced effects on cardiac electrophysiology and on specific biomarkers of pro-arrhythmic risk. To do so, we first perform a thorough literature review of proposed arrhythmic risk biomarkers from the ionic to the electrocardiogram levels. The review highlights the variety of proposed...

Systems biology is currently making a bid to show that it is able to make an important contribution to personalised or precision medicine. In order to do so, systems biologists need to find a way of tackling the pervasive variability of biological systems that is manifested in the medical domain as inter-subject variability. This need is simultaneously social and epistemic: social as systems bi...