نتایج جستجو برای: eet index
تعداد نتایج: 396923 فیلتر نتایج به سال:
OBJECTIVE Epoxyeicosatrienoic acids (EETs) are protective in both myocardial and brain ischemia, variously attributed to activation of K(ATP) channels or blockade of adhesion molecule upregulation. In this study, we tested whether EETs would be protective in lung ischemia-reperfusion injury. METHODS The filtration coefficient (K(f)), a measure of endothelial permeability, and expression of th...
Epoxyeicosatrienoic acids (EETs), the cytochrome P-450 epoxygenase metabolites of arachidonic acid, are candidates of endothelium-derived hyperpolarizing factors. We have previously reported that EETs are potent activators of cardiac ATP-sensitive K(+) (K(ATP)) channels, but their effects on the vascular K(ATP) channels are unknown. With the use of whole cell patch-clamp techniques with 0.1 mM ...
Dissimilatory metal reducing bacteria are capable of extracellular electron transfer (EET) to insoluble metal oxides as external electron acceptors for their anaerobic respiration, which is recognized as an important energy-conversion process in natural and engineered environments, such as in mineral cycling, bioremediation, and microbial fuel/electrolysis cells. However, the low EET efficiency...
Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids. EETs are formed from arachidonic acid during myocardial ischemia and play a protective role against ischemic cell death. Deletion of sEH has been shown to be protective against myocardial ischemia in the isolated heart preparation. We tested the hypothesis that sEH inactivation by targ...
BACKGROUND Preeclampsia is a multisystem disorder of pregnancy, originating in the placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are mechanistically important in preeclampsia. METHODS AND RESULTS We performed microarray screening of placenta and decidua (maternal placenta) from 25 preeclamptic women and 23 control subje...
Lunar meteorite EET 96008 is a fragmental breccia that predominantly consists of basaltic mineral clasts (0.5–2 mm), along with minor lithic fragments and breccia clasts. The matrix consists mainly of smaller mineral fragments ( 0.5 mm), bound by glassy cement, the majority of which are pyroxene and plagioclase. The pyroxene possesses extensive exsolution lamellae. These lamellae, up to 1 m in ...
http://dx.doi.org/10.1016/j.mehy.2015.09.027 0306-9877/ 2015 Elsevier Ltd. All rights reserved. Bone marrow (BM)-derived endothelial progenitor cells (EPCs) have shown regenerative potential in myocardial ischemic animal models with respect to cardiomyocyte formation and neoangiogenesis [1]. Paul et al. [2,3] reported that aerobic exercise-based cardiac rehabilitation in patients with coronary ...
Infiltrating neutrophils are known to promote in the development of tumor. However, it is unclear whether and how neutrophils are involved in triggering the growth of dormant metastases. Here we show that 14,15-epoxyeicosatrienoic acid (14,15-EET) can trigger the growth of dormant micrometastases by inducing neutrophilic infiltration and converting neutrophil function. 14,15-EET triggered neutr...
Background. Dipyridamole echocardiography test (DET: two-dimensional echocardiographic monitoring with dipyridamole infusion up to 0.84 mg/kg in 10 minutes) is a useful tool for the noninvasive diagnosis of coronary artery disease. Aims of the present study were to assess the effects of antianginal drugs on dipyridamole-induced ischemia and to evaluate whether drug-induced changes in DET respon...
Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid through cytochrome P450 (CYP) epoxygenases have many biological functions. Importantly, CYP epoxygenase-derived EETs are involved in the maintenance of cardiovascular homeostasis. In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties, inhibit platelet aggregation, promote fibrinoly...
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