Objective Ischemia-reperfusion (I/R) injury is tissue damage occurring when blood returns to a after an ischemic phase. Reperfusion initiates cascade of acute inflammatory processes that end in cell death, malfunction, and necrosis. Edaravone (3-methy-1-pheny1-2-pyrazolin-5-one) powerful unique synthetic radical scavenger. In this research, the effects edaravone on I/R were investigated. Materi...


 La esclerosis lateral amiotrófica es una enfermedad progresiva que se caracteriza por la degeneración de las neuronas motoras en el cerebro y médula espinal. Existen dos formas fundamentales esta enfermedad: forma esporádica familiar. Aún no existe claridad sobre su etiología. Las manifestaciones clínicas incluyen signos daño superiores e inferiores, tanto extremidades como musculatura b...

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-...

AIM To determine whether ONO-1078 [pranlukast, 4-oxo-8-[p-(4-phenylbutyloxy)benzoyl-amono]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate], a potent leukotriene receptor antagonist, possesses a neuroprotective effect on global cerebral ischemia in rats, and to explore its possible mechanism of action. METHODS Transient global cerebral ischemia was induced by four-vessel occlusion for 10 min an...

In this study, we hypothesized that total flavonoid of Litsea coreana leve (TFLC) protects against focal cerebral ischemia/reperfusion injury. TFLC (25, 50, 100 mg/kg) was administered orally to a rat model of focal ischemia/reperfusion injury, while the free radical scavenging agent, edaravone, was used as a positive control drug. Results of neurological deficit scoring, 2,3,5-triphenyl tetraz...

Quantum chemical calculations at the B3LYP/6-31G* level of theory were employed for the structure-activity relationship and prediction of the antioxidant activity of edaravone and structurally related derivatives using energy (E), ionization potential (IP), bond dissociation energy (BDE), and stabilization energies (ΔE(iso)). Spin density calculations were also performed for the proposed antiox...