BACKGROUND Extracellular volume fraction (ECV) is altered in pathological cardiac remodeling and predicts death and arrhythmia. ECV can be quantified using cardiovascular magnetic resonance (CMR) T1 mapping but calculation requires a measured hematocrit (Hct). The longitudinal relaxation of blood has been used in adults to generate a synthetic Hct (estimate of true Hct) but has not been validat...

An experimental setup has been developed for successive photo-electrochemical etch and EIS measurement of semiconductor samples. Furthermore an algorithm based on electrochemical capacitance-voltage (ECV) has been developed for calculating dopant profile based on the measurements by developed setup. Phosphorous diffusion profile in p-type silicon was estimated by employing developed setup and a...

BACKGROUND Myocardial T1, T2 and T2* imaging techniques become increasingly used in clinical practice. While normal values for T1, T2 and T2* times are well established for 1.5 Tesla (T) cardiovascular magnetic resonance (CMR), data for 3T remain scarce. Therefore we sought to determine normal reference values relative to gender and age and day to day reproducibility for native T1, T2, T2* mapp...

OBJECTIVE To investigate whether initiating external cephalic version (ECV) earlier in pregnancy might increase the rate of successful ECV procedures, and be more effective in decreasing the rate of non-cephalic presentation at birth and of caesarean section. DESIGN An unblinded multicentred randomised controlled trial. SETTING A total of 1543 women were randomised from 68 centres in 21 cou...

OBJECTIVES The goal of this study was to assess the relationship among extracellular volume (ECV), native T1, and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH), hypertensive patients without LVH (HTN non-LVH), and normotensive controls. BACKGROUND Diffuse myocardial fibrosis in HTN LVH patients, as reflected by increased ECV and native T1, may be an unde...

Methods T1 mapping was implemented into a standard CMR protocol in 113 patients with clinically suspected myocarditis at 1.5 Tesla. T1 quantification was performed for ECV -calculation using the modified Look-Locker inversionrecovery (MOLLI) sequence on three short-axes before and 15 minutes after administration of 0.075 mmol/kg gadolinium BOPTA, respectively. Global left ventricular ECV was ca...

Background The extracellular volume fraction (ECV) by T1 mapping measures the size of the myocardial interstitium. T1 changes in blood and myocardium are used to measure the contrast partition coefficient (l), and substituting in the blood volume of distribution (directly measured on a peripheral blood sample as one minus the hematocrit [Hct]) provides the ECV. This methodology is however cumbe...

Background Late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) is a common finding in patients with hypertrophic cardiomyopathy (HCM), and its extent correlates with clinical parameters such as ventricular tachycardia and sudden cardiac death. While LGE has been shown to reflect focal replacement fibrosis, recently optimized T1 mapping techniques have allowed for the quantific...

Background Study purpose To detect differences in extracellular volume (ECV) and systolic strain in hypertensive patients with LVH as compared to hypertensive patients without LVH and age-matched controls. Background: Increased ECV due to diffuse myocardial fibrosis in hypertensive patients may be an underlying mechanism contributing to increased cardiovascular risk. Moreover HTN patients with ...

Background Diffuse myocardial fibrosis may be quantified with cardiovascular magnetic resonance (CMR) by calculating extra-cellular volume (ECV) from native and post-contrast T1 values. Previous studies have used either infusion or single bolus contrast administration. In clinical practice however split dose contrast injection is used as part of a stress/rest protocol in stress perfusion studie...