Transgenic mice were generated to express a restrictive cardiomyopathy (RCM) human cardiac troponin I (cTnI) R192H mutation in the heart (cTnI(193His) mice). The objective of this study was to assess cardiac function during the development of diastolic dysfunction and to gain insight into the pathophysiological impact of the RCM cTnI mutation. Cardiac function and pathophysiological changes wer...

we investigated the vasodilatory effect of isoprenaline at large vessels (aorta, renal ans saphenous arteries, vena cava, renal and saphenous veins) in doxorbicin-induced model of heart failure. thirty saline-treated (normal group) and thirty doxorubicin treated rabbits (1 mg/kg administered intravenously twice weekly for 8 weeks) were studied after 16 weeks of treatment. chronic heart failure ...

background: cardiac resynchronization therapy (crt) is an effective treatment for patients with moderate to severe heart failure. however, 20-30% of patients remain non-responders to crt. we sought to identify which patients benefit the most from crt in regard to the etiology of heart failure. methods: eighty-three consecutive patients (62 men) who had a biventricular pacemaker inserted at tehr...

background: we sought to determine the frequency of the risk factors for congestive cardiac failure (ccf) in a tertiary care hospital in peshawar, pakistan. methods: this retrospective, observational study was conducted in the department of cardiology, postgraduate medical institute, lady reading hospital peshawar, from march 2005 to september 2007. relevant information regarding the risk facto...

background: there is some evidence indicating improvement in myocardial performance after atrial septal defect closure, either device closure or surgical, but ventricular dyssynchrony has not been evaluated before and after surgical closure. the aim of this study was to evaluate ventricular mechanical dyssynchrony in patients with atrial septal defect before and after surgical closure. methods:...

diffuse hepatic inltration is an unusual form of hodgkin's disease (hd). its manifestation as progressive hepatitis or with hepatic failure is even rarer and can be difcult to diagnose. we aim to describe an unusual case of liver failure due to hd. a middle-aged woman with a 10 month history of daily febrile episodes, constitutional symptoms and strikingly high levels of serum ferritin was admi...

OBJECTIVES To determine the prevalence of isolated left ventricular noncompaction (IVNC) as a cause of heart failure and heart transplantation. METHODS There were 960 patients seen in the heart failure clinic from 1987 to 2005, with a complete evaluation including echocardiography at our center (study population, 82% men, mean age 52 years). The following data were collected: type of heart di...

Trastuzumab-related cardiac dysfunction may be manageable and completely reversible with suitable cardiac medication, allowing optimal breast cancer treatment to continue. We present the case of a 42-year-old woman who developed severe systolic left ventricular failure with impaired contractility of the right ventricle, pulmonary hypertension, and clots in the left ventricular cavity during adj...