Seroepidemiological surveys were conducted to determine the frequency and distribution of haemorrhagic fever virus (HFV) activity in the Central African Republic. Human serum specimens (4295) were collected from 5 ecologically distinct zones. Serological evidence of HFV activity was found in all the zones. The filovirus antibody prevalence (24.4%, 1051/4295) was greater than the combined preval...

Crimean–Congo haemorrhagic fever (CCHF), also known as Asian Ebola, is a fatal viral disease that is rapidly increasing worldwide [1,2]. CCHF is a tickborne viral infection characterized by liver dysfunction, ecchymosis, extensive bleeding with shock and disseminated intravascular coagulation [3–5]. The causative agent of CCHF is the virus of genus Nairovirus and family Bunyaviridae [3–6]. The ...

Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting ...

Ebola Virus Disease is a severe illness that starts with a sudden onset of fever, intense weakness, muscle pain, headache and sore throat. This is followed by vomiting, diarrhea, rash, impaired kidney and liver function, and both external and internal bleeding, according to the WHO. Ebola is not spread through the air or by water, or in general, by food. However, in Africa, Ebola may be spread ...