PURPOSE Extranodal NK/T-cell lymphoma, nasal type (ENKL) is closely associated with Epstein-Barr virus (EBV). To elucidate its pathogenetic role, we examined the expression profiles of EBV-encoded proteins, especially focusing on latent membrane protein 1 (LMP1). EXPERIMENTAL DESIGN Immunohistochemistry was carried out using clinical samples from ENKL cases, which were diagnosed between 1996 ...

Purpose: Extranodal NK/T-cell lymphoma, nasal type (ENKL) is closely associated with Epstein-Barr virus (EBV). To elucidate its pathogenetic role, we examined the expression profiles of EBV-encoded proteins, especially focusing on latent membrane protein 1 (LMP1). Experimental design: Immunohistochemistry was performed using clinical samples from ENKL cases, which were diagnosed between 1996 an...

AIMS Mechanisms of Epstein-Barr virus (EBV) associated gastric tumour development are incompletely understood. The interrelations between EBV infection, apoptosis, cell proliferation, and the expression of the tumour suppressor gene p53 was investigated in 133 early stage gastric carcinomas. METHODS Tumour tissue was compared with paired non-tumour tissue. EBV encoded small RNAs (EBERs) deter...

AIMS To develop a rapid, sensitive, and specific non-isotopic in situ hybridisation (NISH) procedure for the detection of Epstein-Barr virus in formalin fixed, paraffin wax embedded tissues. METHODS Two low molecular weight RNAs, designated EBER-1 and EBER-2 (Epstein-Barr encoded RNA), were used: cells latently infected with EBV secrete large amounts of EBERs. The method uses digoxigenin labe...

THE ANCIENT WORLD AND THE BIRTH OF MEDICINE From the banks of the Nile to the shores of the Mediterranean, it is in the land of Egypt where medicine probably started. This is the story of a great period in the history of medicine. But let us start at the beginning. Imhotep, who flourished about 5,000 years ago, is the first person whose name is recorded not for being a king or a conqueror, but ...

A review of the diagnostic skills and therapeutic acumen of physicians in ancient times requires the availability of written records. One might argue that since the Chinese and the Sumerians introduced writing around 5000 BC, they were probably the first to make medical notes. However, there is general agreement among medical historians that the written history of medicine began in Egypt 3000 y...

Abstract The search for an effective treatment acne dates back to 1550 Bc with the Ebers Papyrus, one of oldest medical documents in world, mentioning application raw honey and sulfur affected areas. King Tutankhamun is widely believed have suffered from as his tomb was filled popular treatments time such sulfur, sour milk, Aloe vera, myrrh salt rid him affliction afterlife. Much like Egyptians...

Neurology 2008;71:620–621 Since the emergence of the modern therapeutic era in multiple sclerosis (MS), the field has focused on identifying agents to prevent long-term disability progression. In lieu of measuring the true endpoint of interest, long-term disability progression, clinical trials typically measure surrogate endpoints, such as short-term disability progression or changes in lesion ...

This paper provides a managerial account of network governance by exploring how initially non-powerful agents, driven by the quest for distinctive identity, shape the governance of their networks over time. The research design is that of a longitudinal comparative case study of the trajectories of three renowned, Oscar-winning Spanish filmmakers. It scrutinizes data coming from original intervi...