introduction: the purpose of this study was to determine alkaline phosphatase (alp) activity of ovary after ovarian induction using pregnant mare serum gonadotropin (pmsg) and human chorionic gonadotropin (hcg) during implantation periods. material and methods: a total of 240 female nmri mice aged 6-10 weeks were selected and divided into control and hyperstimulated. these mice were rendered no...

This paper reviews current screening techniques as well as novel biomarkers and their potential role in early detection of ovarian cancer. Ovarian cancer is one of the most common reproductive cancers and has the highest mortality rate amongst gynecologic cancers. Because most ovarian cancer diagnoses occur in the late stages of the disease, five-year survival rates fall below 20%. To improve s...

Optimality theories of ageing predict that the balance between reproductive effort and somatic maintenance determines the rate of ageing. Laboratory studies find that increased reproductive effort shortens lifespan, but through increased short-term mortality rather than ageing. In contrast, high fecundity in early life is associated with accelerated senescence in free-living vertebrates, but th...

Ovarian cancer is the most lethal gynecologic malignancy and the five-year survival rate is only 35% after diagnosis. Epithelial ovarian cancer is a highly metastatic disease characterized by widespread peritoneal dissemination and ascites. The death incidences from ovarian cancer could be significantly lowered by developing new methods for the early diagnosis and treatment of this fatal diseas...

OBJECTIVE Chronic musculoskeletal pain is common in older adults but the nature of its relationship with ageing is unclear. The objective for this study was to test the hypothesis that the onset of widespread pain would be associated with a decrease in healthy ageing. METHODS Population-based prospective cohort study. A "healthy ageing" index was constructed across biomedical, physical, psych...

Discourses on old age and ageing are framed in narrow and binary ways, either as a decline narrative or through discourses of positive and successful ageing. The decline narrative, on the one hand, is highly centred on the decline of the ageing body as frail, leaky and unbounded, and on how old age is characterised by non-productivity, increasing passivity and dependency. Discourses on successf...

Infertility is a main manifestation of endometriosis, though the exact pathogenesis endometriosis-associated infertility remains unclear. Compromised ovarian functions may be one causes endometriosis related infertility. The function can classified into three basic elements, (1) production hormones, (2) maintenance follicular development until ovulation, and (3) reservoir dormant oocytes (ovari...