The full scale aircraft fatigue test(FSAFT)is crucial for determining the fatigue life (or service life based on flight hours) of an aircraft group and for understanding its performance during whole service life. So far, FSAFT is the only means in correctly obtaining the fatigue life of an aircraft group. The early locating and finding repairable cracks and damages in critical structures of the...

Objective Early detection of limited physical activity and nutritional deficiencies in cancer survivors could contribute to early treatment and preservation of quality of life. The aim of this study is to describe the association of physical condition and nutritional status with fatigue and quality of life in oncological out-patients. Methods Data in this descriptive study was collected on bi...

Three patients with chronic obstructive pulmonary disease developed coexisting Mycobacterium malmoense and aspergillus infection. All suffered progressive lung destruction leading to early death despite prolonged antimycobacterial chemotherapy.

A 56 year old man with ankylosing spondylitis and discovertebral destruction presented with signs of spinal cord compression that was the result of the soft tissue reaction occurring at the level of the discovertebral destruction. This case emphasises the importance of early recognition, use of appropriate imaging techniques (computed tomographic myelography or magnetic resonance), and operativ...

Rheumatoid arthritis (RA) is a representative inflammatory disease characterized with systemic, chronic and destructive synovitis and subsequent bone destruction that causes severe disability and mortality. Since joint destruction occurs from the early disease, its diagnosis and treatment have to be done timely. The combinational use of methotrexate and biologics targeting TNF and IL-6 has revo...

The completion of mitosis depends on protein ubiquitination by the anaphase-promoting complex (APC). The APC is activated by association with Cdc20 in midmitosis and Cdh1 in late mitosis and G1. Here, we show that in budding yeast the activation of APC(Cdh1) is controlled in part by destruction of the Cdh1 inhibitor Acm1. We find that Acm1 uses pseudosubstrate and other sequence motifs to bind ...

Galactic destruction of primordial deuterium is inevitably linked through star formation to the chemical evolution of the Galaxy. The relatively high present gas content and low metallicity suggest only modest D-destruction. In concert with deuterium abundances derived from solar system and/or interstellar observations this suggests a primordial deuterium abundance in possible conflict with dat...

Measurements of the intracellular free concentration of Ca2+ ([Ca2+]i) were performed during fatiguing stimulation of intact, single muscle fibers, which were dissected from a mouse foot muscle and loaded with fura-2. Fatigue, which was produced by repeated 100-Hz tetani, generally occurred in three phases. Initially, tension declined rapidly to approximately 90% of the original tension (0.9 Po...

Fatigue-related changes in lifting kinematics may expose workers to undue injury risks. Early detection of accumulating fatigue offers the prospect of intervention strategies to mitigate such fatigue-related risks. In a first step towards this objective, this study investigated whether fatigue detection was accessible to visual perception and, if so, what was the key visual information required...

BACKGROUND Fatigue is common after traumatic brain injury (TBI). Its risk factors, natural history and consequences are uncertain. Best-evidence synthesis was used to address the gaps. METHODS Five databases were searched for relevant peer-reviewed studies. Of the 33 articles appraised, 22 longitudinal studies were selected. Results were reported separately based on their timing of baseline a...